Metaraminol is a sympathomimetic amine and adrenergic agonist used primarily as a vasopressor to increase blood pressure in situations involving acute hypotension. It produces vasoconstriction and increases vascular tone through activity at adrenergic receptors.
Metaraminol is an important cardiovascular pharmaceutical API used in the development and manufacture of injectable medicines for the management of clinically significant hypotension.
Metaraminol is a specialized vasopressor API used for pharmaceutical formulation and research. Its manufacture requires appropriate control of identity, assay, related substances, stereochemical purity, residual solvents and other applicable quality parameters.
CAS Number: 54-49-9
Molecular Formula: C9H13NO2
Molecular Weight: 167.21 g/mol
Chemical Name: Metaraminol
Drug Class: Sympathomimetic / Adrenergic Agonist
Therapeutic Class: Vasopressor
Therapeutic Area: Cardiovascular / Critical Care
Molecule Type: Synthetic Small Molecule
Metaraminol acts primarily through adrenergic receptor stimulation, producing peripheral vasoconstriction and increasing vascular resistance. It also has an indirect sympathomimetic component through promotion of norepinephrine release.
Its pharmacological effects include:
Metaraminol API is associated with pharmaceutical applications involving:
Metaraminol is primarily used in parenteral pharmaceutical preparations, particularly injectable formulations intended for controlled clinical administration.
Metaraminol is generally handled as a pharmaceutical solid or as an appropriate salt form for formulation. Appearance, solid-state properties and other physical characteristics should be controlled according to the applicable API specification.
A controlled Metaraminol API manufacturing process may involve:
Typical Metaraminol API testing may include:
Store Metaraminol API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Metaraminol is relevant to research involving:
Metaraminol is a sympathomimetic vasopressor with CAS Number 54-49-9, molecular formula C9H13NO2, and molecular weight 167.21 g/mol. It is primarily associated with the management of acute hypotension through adrenergic-mediated vasoconstriction.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |