Metacycline is a semi-synthetic tetracycline-class antibiotic with broad-spectrum antibacterial activity. It belongs to the tetracycline family and acts primarily by inhibiting bacterial protein synthesis.
Metacycline is structurally related to tetracycline and has been used in pharmaceutical preparations for the treatment of susceptible bacterial infections.
Metacycline has the molecular formula C22H22N2O8 and a molecular weight of approximately 442.42 g/mol. Its CAS Number is 3963-95-9.
It is a tetracycline derivative containing multiple functional groups characteristic of this antibiotic class. Metacycline is generally supplied as a pharmaceutical-grade active ingredient or in an appropriate salt/formulation form.
Metacycline exerts its antibacterial activity primarily by binding reversibly to the 30S bacterial ribosomal subunit. This interferes with the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and inhibits bacterial protein synthesis.
The resulting inhibition of protein production produces a predominantly bacteriostatic antibacterial effect.
Metacycline has been used for susceptible bacterial infections and tetracycline-class pharmaceutical formulations.
Applications include:
Use should be based on the approved indication, susceptibility profile and regulatory status of the relevant formulation and market.
Metacycline API can be evaluated using validated analytical methods for identity, assay, related substances, water content, residue on ignition, residual solvents and elemental impurities, as applicable.
Chromatographic and spectroscopic methods may be used to establish identity, potency and impurity profile. Because tetracycline derivatives can be sensitive to environmental conditions, appropriate control of storage and handling is important.
Final acceptance criteria should follow the manufacturer's validated drug-substance specification and current Certificate of Analysis.
Metacycline should be stored in a tightly closed pharmaceutical-grade container in a cool, dry environment and protected from excessive moisture and light.
Specific storage conditions should follow the manufacturer's approved specification.
Metacycline API may be supplied for qualified pharmaceutical manufacturing, formulation development, analytical and research applications, subject to applicable quality and regulatory requirements.
Metacycline is a specialized tetracycline-class pharmaceutical API intended for qualified pharmaceutical and formulation applications. Product specifications, Certificate of Analysis, analytical documentation and packaging information can be provided according to applicable requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 5.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 5.0% |