Mesuximide API Manufacturer in India

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Mesuximide API

Mesuximide is an anticonvulsant pharmaceutical compound belonging to the succinimide class of antiepileptic agents. It has historically been used in the management of certain epileptic seizure disorders, particularly absence-type seizures.

Mesuximide is a specialized neurological pharmaceutical API relevant to anticonvulsant research and pharmaceutical development.

Mesuximide API Manufacturer in India

Mesuximide is a specialized antiepileptic API used in pharmaceutical research and formulation development. Its quality control requires careful assessment of identity, assay, related substances, residual solvents and other applicable pharmaceutical parameters.

Chemical Information

CAS Number: 1269-77-8
Molecular Formula: C12H15NO2
Molecular Weight: 205.26 g/mol
Chemical Name: Mesuximide
Drug Class: Succinimide Anticonvulsant
Therapeutic Class: Antiepileptic
Therapeutic Area: Neurology
Molecule Type: Synthetic Small Molecule

Mechanism of Action

Mesuximide belongs to the succinimide anticonvulsant group. Its anticonvulsant activity is associated with suppression of abnormal neuronal activity and reduction of seizure susceptibility.

Its pharmacological activity is particularly associated with mechanisms involved in absence seizures, although the precise molecular mechanism of mesuximide is not fully established.

Pharmaceutical Applications

Mesuximide has historically been associated with:

  • Epilepsy
  • Absence seizures
  • Seizure-disorder research
  • Anticonvulsant drug development
  • Succinimide-class pharmacology
  • Neurological pharmaceutical research

Dosage Form Applications

Mesuximide has historically been administered in oral pharmaceutical formulations, depending on the applicable product and regulatory market.

Physical Characteristics

Mesuximide is handled as a solid pharmaceutical substance. Its exact appearance, crystalline characteristics and particle properties should be controlled according to the applicable API specification.

Manufacturing Process

A controlled Mesuximide API manufacturing process may involve:

  1. Selection and qualification of starting materials
  2. Preparation of required synthetic intermediates
  3. Controlled synthesis of the succinimide structure
  4. Purification
  5. Crystallization or isolation
  6. Filtration
  7. Controlled drying
  8. Milling or sieving where required
  9. Final analytical testing
  10. Pharmaceutical-grade packaging

Quality Control Testing

Typical Mesuximide API testing may include:

  • Identification by IR
  • HPLC identification
  • Assay
  • Related substances
  • Water content
  • Residual solvents
  • Elemental impurities
  • Residue on ignition
  • Melting range
  • Particle-size distribution where applicable
  • Stability testing

Storage

Store Mesuximide API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.

Pharmaceutical Research

Mesuximide is relevant to research involving:

  • Epilepsy
  • Absence seizures
  • Anticonvulsant pharmacology
  • Succinimide antiepileptics
  • Neuronal excitability
  • Seizure mechanisms
  • CNS drug development
  • Neurological pharmaceutical research

Mesuximide API Summary

Mesuximide is a succinimide-class anticonvulsant with CAS Number 1269-77-8, molecular formula C12H15NO2, and molecular weight 205.26 g/mol. It has historically been associated with the treatment of epilepsy, particularly absence-type seizures.

Detailed Specifications

Parameter Specification
Appearance White to off-white crystalline powder
Identification IR & HPLC compliant
Assay (HPLC) 98.0% – 102.0%
Loss on Drying NMT 2.0%
Residue on Ignition NMT 0.5%
Heavy Metals NMT 10 ppm
pH (1% Solution) 2.0 – 4.0
Individual Impurity NMT 0.5%
Total Impurities NMT 1.0%
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