Meprobamate is a carbamate-class central nervous system (CNS) depressant with anxiolytic and sedative properties. It has historically been used for the short-term management of anxiety and tension and as a skeletal muscle relaxant.
Meprobamate is a synthetic pharmaceutical compound that acts primarily through modulation of inhibitory neurotransmission in the CNS.
Meprobamate is a specialized CNS pharmaceutical API used in pharmaceutical research and formulation development. Because it is a centrally acting compound, its manufacture and handling require appropriate quality and regulatory controls.
Key quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and stability characteristics, according to the applicable API specification.
CAS Number: 57-53-4
Molecular Formula: C9H18N2O4
Molecular Weight: 218.25 g/mol
Chemical Name: Meprobamate
Drug Class: Carbamate
Therapeutic Class: Anxiolytic / Sedative / Skeletal Muscle Relaxant
Therapeutic Area: CNS / Psychiatry
Molecule Type: Synthetic Small Molecule
Meprobamate is a CNS depressant that enhances inhibitory neuronal activity. Its pharmacological effects are associated with reduced neuronal excitability and CNS depression.
Its activity is broadly associated with:
Meprobamate API has historically been associated with:
Historically, Meprobamate has been formulated as:
Its availability and approved applications vary by country because of regulatory restrictions associated with centrally acting sedative/anxiolytic medicines.
Meprobamate is generally described as a white crystalline solid. Its physical and solid-state characteristics should be controlled according to the applicable API specification.
A controlled Meprobamate API manufacturing process may involve:
Typical Meprobamate API testing may include:
Store Meprobamate API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Meprobamate is relevant to research involving:
Meprobamate is a carbamate-class CNS depressant with anxiolytic, sedative and muscle-relaxant properties. It has CAS Number 57-53-4, molecular formula C9H18N2O4, and molecular weight 218.25 g/mol. It has historically been used for anxiety and tension and in skeletal muscle-relaxant applications.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 2.0% |