Mepivacaine is an amide-type local anesthetic used to produce temporary loss of sensation in a localized area. It works by blocking voltage-gated sodium channels in nerve cells, thereby inhibiting the initiation and transmission of nerve impulses.
Mepivacaine is primarily used in local and regional anesthesia, including dental anesthesia and selected surgical or diagnostic procedures.
Mepivacaine is a specialized local anesthetic pharmaceutical API used in the development and manufacture of injectable and dental anesthetic formulations.
Key quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and stereochemical purity, according to the applicable API specification.
CAS Number: 96-88-8
Molecular Formula: C15H22N2O
Molecular Weight: 246.35 g/mol
Chemical Name: Mepivacaine
Drug Class: Amide Local Anesthetic
Therapeutic Class: Local Anesthetic
Therapeutic Area: Anesthesiology / Dentistry
Molecule Type: Synthetic Small Molecule
Mepivacaine produces local anesthesia primarily by reversibly blocking voltage-gated sodium channels in neuronal membranes.
This reduces sodium ion influx and prevents the generation and propagation of action potentials along peripheral nerves.
Its mechanism includes:
Mepivacaine API is used in pharmaceutical development for:
Mepivacaine is commonly used in:
Mepivacaine hydrochloride is the commonly used pharmaceutical salt form.
Mepivacaine is a solid pharmaceutical compound, while its hydrochloride salt is commonly supplied for pharmaceutical formulation. Appearance and solid-state characteristics should be controlled according to the applicable API specification.
A controlled Mepivacaine API manufacturing process may involve:
Typical Mepivacaine API testing may include:
Store Mepivacaine API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Mepivacaine is relevant to research involving:
Mepivacaine is an amide-type local anesthetic with CAS Number 96-88-8, molecular formula C15H22N2O, and molecular weight 246.35 g/mol. It is primarily associated with local and regional anesthesia, including dental procedures and peripheral nerve blocks.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |