Memantine Hydrochloride (Memantine HCl) is an NMDA receptor antagonist used primarily in the management of moderate to severe Alzheimer's disease. It helps regulate excessive glutamatergic activity in the brain by reducing pathological activation of N-methyl-D-aspartate (NMDA) receptors.
Memantine HCl is an important neurological pharmaceutical API used in the manufacture of oral formulations for Alzheimer's disease.
Memantine HCl is a specialized CNS pharmaceutical API used in the development and manufacture of medicines for neurodegenerative disorders.
Key quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and stereochemical purity, according to the applicable API specification.
CAS Number: 41100-52-1
Molecular Formula: C12H22ClN
Molecular Weight: 215.76 g/mol
Chemical Name: Memantine Hydrochloride
Synonyms: Memantine HCl, 1-Amino-3,5-dimethyladamantane hydrochloride
Drug Class: NMDA Receptor Antagonist
Therapeutic Class: Anti-dementia Agent
Therapeutic Area: Neurology / Psychiatry
Molecule Type: Synthetic Small Molecule
Memantine is a low- to moderate-affinity, uncompetitive NMDA receptor antagonist. It preferentially blocks pathological NMDA receptor activity while allowing normal physiological neurotransmission to continue.
Its pharmacological action helps:
Memantine HCl API is used in pharmaceutical development for:
Memantine may be used alone or in combination with other Alzheimer's disease therapies depending on the pharmaceutical product and clinical indication.
Memantine HCl is commonly formulated as:
Memantine Hydrochloride is generally described as a white crystalline powder. Its physical and solid-state characteristics should be controlled according to the applicable API specification.
A controlled Memantine HCl API manufacturing process may involve:
Typical Memantine HCl API testing may include:
Store Memantine HCl API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Memantine HCl is relevant to research involving:
Memantine Hydrochloride is a synthetic NMDA receptor antagonist with CAS Number 41100-52-1, molecular formula C12H22ClN, and molecular weight 215.76 g/mol. It is primarily used in pharmaceutical formulations for the management of moderate to severe Alzheimer's disease.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |