Mecloxamine Citrate is an antihistamine pharmaceutical ingredient belonging to the class of H1 receptor antagonists. It has been used for its antihistaminic and antiemetic properties and is associated with the management of allergic symptoms and motion-related nausea.
Mecloxamine Citrate is a specialized pharmaceutical API used in the development and manufacture of antihistamine and antiemetic formulations.
Important quality attributes include identity, assay, related substances, water content, residual solvents, residue on ignition and elemental impurities, according to the applicable API specification.
CAS Number: 1218-56-6
Molecular Type: Synthetic Small Molecule
Drug Class: H1 Antihistamine
Therapeutic Class: Antihistamine / Antiemetic
Therapeutic Area: Allergy / Gastroenterology
Molecule Type: Synthetic Compound
Mecloxamine acts primarily as an H1 histamine receptor antagonist. By reducing histamine-mediated signaling, it can suppress certain allergic responses.
Its pharmacological activity is associated with:
Mecloxamine Citrate has been associated with pharmaceutical applications involving:
Depending on the applicable pharmaceutical product, Mecloxamine Citrate may be incorporated into:
Mecloxamine Citrate is handled as a solid pharmaceutical substance. Its exact appearance, particle characteristics and solid-state properties should be controlled according to the applicable API specification.
A controlled Mecloxamine Citrate manufacturing process may involve:
Typical API testing may include:
Store Mecloxamine Citrate in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Mecloxamine Citrate is relevant to research involving:
Mecloxamine Citrate is a synthetic H1 antihistamine pharmaceutical ingredient associated with antihistaminic and antiemetic activity. It has CAS Number 1218-56-6 and has been used in pharmaceutical applications involving allergic symptoms and nausea-related conditions.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 1.0% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |