Meclofenamic Acid is a non-steroidal anti-inflammatory drug (NSAID) belonging to the fenamate class. It exhibits anti-inflammatory, analgesic and antipyretic properties and acts primarily by inhibiting cyclooxygenase enzymes involved in prostaglandin synthesis.
Meclofenamic Acid has been used for the management of mild to moderate pain and inflammatory conditions. It is a synthetic small-molecule pharmaceutical compound and is commonly encountered in pharmaceutical development as meclofenamate, particularly in its sodium salt form.
Meclofenamic Acid has the molecular formula C14H11Cl2NO2 and a molecular weight of approximately 296.15 g/mol. Its CAS Number is 644-62-2.
It is a substituted anthranilic acid derivative belonging to the fenamate group of NSAIDs.
Meclofenamic Acid inhibits cyclooxygenase (COX) enzymes, reducing the conversion of arachidonic acid into prostaglandins.
Reduced prostaglandin synthesis contributes to decreased inflammation, pain and fever. Its pharmacological activity is therefore associated with analgesic, anti-inflammatory and antipyretic effects.
Meclofenamic Acid has been used for the treatment of mild to moderate pain and inflammatory conditions. Its pharmaceutical applications include analgesic and anti-inflammatory formulations.
The approved indications and availability of meclofenamic acid products may vary by country and regulatory jurisdiction.
Meclofenamic Acid API can be evaluated using validated analytical methods for identification, assay, related substances, water content, residual solvents, elemental impurities and other applicable quality attributes.
HPLC, infrared spectroscopy and other validated analytical techniques can be used for identity, assay and purity determination. Appropriate controls should be established for process-related impurities and degradation products.
Final acceptance criteria should follow the applicable manufacturer's approved drug-substance specification and Certificate of Analysis.
Meclofenamic Acid should be stored in a tightly closed pharmaceutical-grade container under controlled conditions. It should be protected from excessive heat, moisture and direct light.
Specific storage and transportation requirements should follow the applicable manufacturer's approved specification.
Meclofenamic Acid API may be supplied for qualified pharmaceutical manufacturing, formulation development, analytical and research applications, subject to applicable quality and regulatory requirements.
Meclofenamic Acid API is available for qualified pharmaceutical development and manufacturing requirements. Customers can request product specifications, Certificate of Analysis, analytical documentation, packaging information and commercial details according to their requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 1.0% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |