Meclocycline is a tetracycline-class antibiotic with broad-spectrum antibacterial activity. It is primarily used in topical dermatological formulations, particularly for the management of acne and other susceptible bacterial skin conditions.
Meclocycline is commonly formulated as meclocycline sulfosalicylate, a salt form used in topical pharmaceutical products.
Meclocycline is a specialized dermatological pharmaceutical API used in the development and manufacture of topical antibacterial formulations.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and microbiological quality, according to the applicable API specification.
CAS Number: 7381-01-3
Molecular Formula: C21H21N3O8
Molecular Weight: 443.41 g/mol
Chemical Name: Meclocycline
Common Pharmaceutical Form: Meclocycline Sulfosalicylate
Drug Class: Tetracycline Antibiotic
Therapeutic Class: Topical Antibacterial
Therapeutic Area: Dermatology
Molecule Type: Semi-Synthetic Antibiotic
Meclocycline is a tetracycline antibiotic that inhibits bacterial protein synthesis.
It binds primarily to the 30S ribosomal subunit of susceptible bacteria and interferes with the attachment of aminoacyl-tRNA to the ribosomal complex.
This inhibits bacterial protein synthesis and suppresses bacterial growth.
Its mechanism includes:
Meclocycline API is used in pharmaceutical development for:
Meclocycline has historically been used primarily in topical dermatological preparations, particularly for acne. Topical delivery allows the active ingredient to be applied directly to affected skin.
Meclocycline may be incorporated into:
Meclocycline is generally handled as a yellow to yellow-orange solid/powder, depending on the chemical form and grade. Physical characteristics should be controlled according to the applicable API specification.
A controlled Meclocycline manufacturing process may involve:
Typical Meclocycline API testing may include:
Store Meclocycline API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Meclocycline is relevant to research involving:
Meclocycline is a tetracycline-class antibacterial pharmaceutical ingredient primarily associated with topical dermatological formulations. It has CAS Number 7381-01-3, molecular formula C21H21N3O8, and molecular weight 443.41 g/mol. Its antibacterial activity results from inhibition of bacterial protein synthesis through interaction with the 30S ribosomal subunit.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |