Mazdutide is a long-acting synthetic oxyntomodulin analogue that acts as a dual glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) agonist. It is a peptide-based pharmaceutical compound developed for metabolic diseases, particularly obesity and type 2 diabetes.
Mazdutide is also known by the development codes IBI-362 and LY3305677. It is administered by subcutaneous injection and has been approved in China.
Mazdutide is a specialized peptide pharmaceutical API requiring controlled peptide synthesis, purification and comprehensive analytical characterization.
Important quality attributes include identity, peptide purity, assay, related peptides, aggregation, residual solvents, water content, peptide mapping and biological activity.
CAS Number: 2259884-03-0
Molecular Formula: C210H322N46O67
Molecular Weight: 4563.06 g/mol
Synonyms: IBI-362, IBI362, LY3305677, OXM-3
Development Code: IBI-362 / LY3305677
Drug Class: Dual GLP-1/Glucagon Receptor Agonist
Therapeutic Class: Metabolic Agent
Therapeutic Area: Obesity / Type 2 Diabetes
Molecule Type: Synthetic Peptide
The FDA Global Substance Registration System lists CAS 2259884-03-0 for Mazdutide. The molecular formula and mass have some database discrepancies; the formula C210H322N46O67 and molecular weight 4563.06 g/mol are consistent with commonly reported structural records.
Mazdutide is a dual agonist of GLP-1 and glucagon receptors.
Its activity includes:
The combination of GLP-1 and glucagon receptor activity is intended to provide complementary effects on glucose regulation, appetite and energy expenditure.
Mazdutide is used/developed for:
Mazdutide is developed as a subcutaneous injectable peptide pharmaceutical and is administered on a long-acting dosing schedule.
Mazdutide is a modified peptide molecule derived from the oxyntomodulin concept. Its structure incorporates peptide modifications and a lipid-containing conjugate designed to extend pharmacological duration.
As a peptide API, critical quality attributes include:
A controlled Mazdutide API manufacturing process may involve:
Typical Mazdutide peptide API testing may include:
Mazdutide peptide API should be stored under validated temperature and humidity conditions, protected from moisture, excessive heat and light. Because peptide stability can be sensitive to environmental conditions, final storage requirements should follow the manufacturer's validated stability data.
Mazdutide is relevant to research involving:
Mazdutide is a long-acting dual GLP-1 and glucagon receptor agonist and synthetic peptide. It has CAS Number 2259884-03-0, commonly reported molecular formula C210H322N46O67, and molecular weight 4563.06 g/mol. It is primarily associated with obesity, weight management and metabolic-disease applications.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Water Content | NMT 2.0% |