Maropitant is a neurokinin-1 (NK1) receptor antagonist used primarily as an antiemetic veterinary pharmaceutical ingredient. It blocks the activity of substance P, an important neurotransmitter involved in the vomiting reflex.
Maropitant is widely used in veterinary medicine for the prevention and treatment of vomiting and nausea in dogs and cats. It is commonly supplied in pharmaceutical formulations as maropitant citrate.
Maropitant is a specialized veterinary pharmaceutical API used in the manufacture of antiemetic veterinary medicines.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and stability characteristics.
CAS Number: 359875-09-5
Molecular Formula: C32H40N6O·2H3C6H5O7 (Maropitant citrate)
Molecular Weight: 678.75 g/mol (Maropitant citrate)
Chemical Name: Maropitant
Common Form: Maropitant Citrate
Drug Class: Neurokinin-1 (NK1) Receptor Antagonist
Therapeutic Class: Antiemetic
Therapeutic Area: Veterinary Medicine
Molecule Type: Synthetic Small Molecule
Maropitant selectively antagonizes NK1 receptors and prevents the binding of substance P.
Substance P is involved in transmission of signals associated with nausea and vomiting. By blocking NK1 receptor activation, Maropitant helps inhibit the final common pathway of the vomiting reflex.
Its mechanism includes:
Maropitant API is used in veterinary formulations for:
Maropitant is primarily associated with canine and feline veterinary medicine. It can be administered in different dosage forms depending on the veterinary product and indication.
Maropitant may be developed into:
Maropitant citrate is generally handled as a solid pharmaceutical substance. The appearance, particle characteristics and other physical properties should be controlled according to the applicable API specification.
A controlled Maropitant API manufacturing process may involve:
Typical Maropitant API testing may include:
Store Maropitant API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage conditions should follow the manufacturer's validated stability data.
Maropitant is relevant to research involving:
Maropitant is a selective NK1 receptor antagonist used as a veterinary antiemetic. It blocks substance P-mediated signaling and is primarily used in dogs and cats to prevent and treat vomiting. The commonly marketed pharmaceutical form is maropitant citrate.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |