Magnesium Oxide is an inorganic compound consisting of magnesium and oxygen. It is widely used as a pharmaceutical, nutraceutical, food, and industrial ingredient. In pharmaceutical applications, Magnesium Oxide is primarily used as a magnesium supplement, antacid, and osmotic laxative.
Magnesium Oxide is available in different grades and physical forms, including light magnesium oxide and heavy magnesium oxide, with differences in bulk density, particle characteristics and manufacturing properties.
Magnesium Oxide is an important mineral pharmaceutical ingredient used in the manufacture of oral pharmaceutical and nutraceutical products.
Its quality is typically evaluated through parameters such as identity, assay, loss on ignition, acid-insoluble substances, chloride, sulfate, heavy metals/elemental impurities, particle characteristics and microbial quality where applicable.
CAS Number: 1309-48-4
Molecular Formula: MgO
Molecular Weight: 40.30 g/mol
Chemical Name: Magnesium Oxide
Synonyms: Magnesia, Magnesium Oxide
Drug Class: Mineral Supplement / Antacid
Therapeutic Class: Mineral Supplement / Gastrointestinal Agent
Therapeutic Area: Gastroenterology / Nutritional Supplementation
Molecule Type: Inorganic Compound
Magnesium Oxide provides elemental magnesium following dissolution in the gastrointestinal tract.
Depending on the formulation and dose, magnesium may:
Magnesium is an essential mineral involved in numerous biochemical processes, including energy metabolism, neuromuscular function and electrolyte balance.
Magnesium Oxide is used in pharmaceutical and nutraceutical formulations for:
Magnesium Oxide is widely incorporated into vitamin and mineral supplements as a source of elemental magnesium. It may be used in tablets, capsules, powders and other oral dosage forms.
Depending on the applicable grade, Magnesium Oxide is also used in:
For pharmaceutical use, the material should meet the relevant pharmaceutical-grade requirements.
Magnesium Oxide is generally a white, fine, odorless powder. It is practically insoluble in water but reacts with acids to form corresponding magnesium salts.
Different grades, particularly light and heavy Magnesium Oxide, can have different bulk density and particle-size characteristics.
A controlled Magnesium Oxide manufacturing process may involve:
Manufacturing parameters can influence the reactivity, surface area, bulk density and physical characteristics of the final Magnesium Oxide grade.
Typical pharmaceutical-grade Magnesium Oxide testing may include:
Store Magnesium Oxide in a tightly closed container in a dry environment, protected from excessive moisture, heat and contamination. Magnesium Oxide can interact with atmospheric moisture and carbon dioxide, so appropriate packaging and storage controls are important.
Magnesium Oxide is relevant to research involving:
Magnesium Oxide is an inorganic magnesium compound with CAS Number 1309-48-4, molecular formula MgO, and molecular weight 40.30 g/mol. It is widely used as a pharmaceutical and nutraceutical source of magnesium and is also utilized in antacid and laxative formulations.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | Approximately 9.0 – 11.0 |
| Individual Impurity | NMT 0.1% |
| Water Content | NMT 1.0% |