Macrogol (PEG), also known as Polyethylene Glycol (PEG), is a water-soluble polyether polymer widely used in pharmaceutical formulations, cosmetics, personal care products, and specialty chemical applications. Pharmaceutical Macrogol grades are available in different average molecular-weight ranges, and the selected grade determines its physical properties and formulation functionality.
Swapnroop Pharma manufactures and supplies Macrogol (PEG) in India for pharmaceutical, nutraceutical, cosmetic, and formulation applications. Different molecular-weight grades can be supplied according to dosage-form requirements and applicable specifications.
Macrogol is widely used as a pharmaceutical excipient and, for specific grades and formulations, as an active pharmaceutical ingredient. Its applications include:
Lower-molecular-weight Macrogols are generally liquids or low-viscosity materials, while higher-molecular-weight grades are typically semi-solid or solid.
Macrogol can perform several formulation functions depending on molecular weight and grade, including:
Higher molecular-weight grades can also be used where a solid or waxy polyethylene glycol is required for pharmaceutical manufacturing.
Macrogol grades are commonly distinguished by their average molecular weight, such as Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 3350, Macrogol 4000, Macrogol 6000 and other specified grades.
The number associated with a Macrogol grade generally indicates its approximate average molecular-weight range rather than representing a single molecular-weight compound.
Grade selection is therefore important because viscosity, physical state, melting/solidification characteristics, hygroscopicity, and formulation performance vary with molecular weight.
Specific higher-molecular-weight grades such as Macrogol 3350 and Macrogol 4000 are widely recognized in pharmaceutical applications, including oral formulations and osmotic preparations.
The regulatory status and intended use depend on the specific product, dosage form, jurisdiction, and applicable pharmacopeial requirements.
Macrogol is a polyether polymer composed of repeating ethylene oxide units. Its general structural representation is:
HO–(CH₂CH₂O)n–H
Unlike a small-molecule chemical, Macrogol does not have one fixed molecular weight. The molecular-weight distribution is controlled during manufacturing and is reflected in the designated grade.
Low-molecular-weight grades may appear as clear, colourless, viscous liquids, while higher grades may occur as white or almost white waxy solids, flakes, powders, or granules.
Swapnroop Pharma supplies pharmaceutical-grade Macrogol (PEG) to pharmaceutical manufacturers, formulation companies, nutraceutical manufacturers, cosmetic companies, and qualified customers.
Supply can be aligned with requirements for molecular-weight grade, physical form, purity, bulk quantity, packaging, documentation, and application-specific specifications.
Macrogol should be stored in tightly closed, suitable containers under the storage conditions specified for the particular molecular-weight grade.
Material should be protected from excessive moisture, contamination, direct sunlight, and unsuitable temperature conditions. Exact storage requirements should follow the applicable SDS, CoA, product specification, and manufacturer's recommendations.
Depending on the selected grade and customer requirements, documentation may include:
Swapnroop Pharma supplies Macrogol (PEG) for pharmaceutical, nutraceutical, cosmetic, topical, oral, and specialty formulation applications in India and international markets.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |