Macimorelin is a synthetic peptidomimetic growth hormone secretagogue and ghrelin receptor agonist used in pharmaceutical and diagnostic applications. Macimorelin acetate is the pharmaceutical salt form used as the active drug substance in the approved oral formulation.
Macimorelin has CAS Number 381231-18-1, molecular formula C26H30N6O3, and molecular weight 474.56 g/mol. Macimorelin acetate has CAS Number 945212-59-9 and is supplied as the active ingredient in MACRILEN.
Macimorelin is an orally active synthetic compound that mimics some of the activity of ghrelin. It activates the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor, stimulating the release of growth hormone from the pituitary gland.
Macimorelin acetate is used as a pharmaceutical active ingredient for oral formulation development and is particularly associated with diagnostic testing for adult growth hormone deficiency.
Macimorelin activates growth hormone secretagogue receptors in the pituitary and hypothalamus. This receptor activation mimics the action of ghrelin and stimulates the physiological release of growth hormone.
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of specialty pharmaceutical APIs including Macimorelin and Macimorelin Acetate for qualified pharmaceutical, research and development requirements.
Macimorelin Acetate can be evaluated according to applicable customer specifications, validated analytical methods and relevant pharmaceutical quality requirements. Technical documentation, product specifications, Certificate of Analysis and commercial details can be requested according to the intended application.
Macimorelin has CAS Number 381231-18-1, molecular formula C26H30N6O3, and molecular weight 474.56 g/mol. Macimorelin acetate has CAS Number 945212-59-9 and is also associated with development codes including AEZS-130, ARD-07 and EP-1572.
Macimorelin acetate is the active drug substance in MACRILEN, an oral solution used as a diagnostic test for adult growth hormone deficiency. It is a synthetic growth hormone secretagogue receptor agonist used to stimulate growth hormone release during diagnostic evaluation.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| Individual Impurity | NMT 0.5% |
| Water Content | NMT 1.0% |