Lusutrombopag is an orally active small-molecule thrombopoietin (TPO) receptor agonist used as an active pharmaceutical ingredient in pharmaceutical formulations for thrombocytopenia. It stimulates TPO receptor signaling and supports platelet production by promoting the growth and maturation of megakaryocytes.
Lusutrombopag has CAS Number 1110766-97-6, molecular formula C29H32Cl2N2O5S, and molecular weight 591.54 g/mol. It is a synthetic, nonpeptide TPO receptor agonist supplied for pharmaceutical formulation and research applications.
Lusutrombopag interacts with the transmembrane region of the human thrombopoietin receptor. Unlike naturally occurring thrombopoietin, it is a small-molecule compound that activates TPO receptor signaling and promotes the proliferation and differentiation of megakaryocytic progenitor cells.
It is used in pharmaceutical development for products intended to increase platelet counts in patients with thrombocytopenia associated with chronic liver disease who are scheduled for an invasive procedure.
Lusutrombopag acts as an orally active TPO receptor agonist. It binds to the transmembrane domain of human TPO receptors and activates signaling pathways involved in megakaryocyte proliferation, differentiation and maturation. This results in increased platelet production.
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of Lusutrombopag API for qualified pharmaceutical manufacturing, formulation development and research requirements.
Lusutrombopag can be evaluated according to applicable customer specifications, validated analytical methods and relevant pharmaceutical quality requirements. Technical documentation, product specifications, Certificate of Analysis and commercial details can be requested according to the intended application.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |