Lurasidone Hydrochloride is the hydrochloride salt of lurasidone, an atypical antipsychotic active pharmaceutical ingredient used in formulations for schizophrenia and depressive episodes associated with bipolar depression. It belongs to the benzisothiazole class of pharmaceutical compounds.
Lurasidone Hydrochloride has CAS Number 367514-87-2, molecular formula C28H36Cl2N6O2, and molecular weight 529.54 g/mol. It is used in the development and manufacture of oral pharmaceutical formulations.
Lurasidone Hydrochloride primarily acts on dopamine and serotonin receptors. It has antagonist activity at dopamine D2 and serotonin 5-HT2A receptors, along with activity at serotonin 5-HT7 and 5-HT1A receptors.
The hydrochloride salt is the pharmaceutical form used in drug-product manufacturing. It is a well-characterized small-molecule API suitable for pharmaceutical formulation, analytical development and quality-control applications.
Lurasidone primarily acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors. It also interacts with serotonin 5-HT7 receptors and acts as a partial agonist at 5-HT1A receptors. These combined receptor activities contribute to its pharmacological effects in schizophrenia and bipolar depression.
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of Lurasidone Hydrochloride API for qualified pharmaceutical manufacturing, formulation development and research requirements.
For Lurasidone Hydrochloride API availability, technical documentation, product specifications, Certificate of Analysis and commercial requirements, contact Swapproop Drugs and Pharmaceuticals.
Lurasidone Hydrochloride has CAS Number 367514-87-2, molecular formula C28H36Cl2N6O2, and molecular weight 529.54 g/mol. Its development code is SM-13496, and it is marketed under the brand name LATUDA.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |