Losartan Potassium is an orally active angiotensin II receptor blocker (ARB) used primarily in the treatment of hypertension. It selectively blocks the binding of angiotensin II to the AT1 receptor, reducing vasoconstriction and aldosterone-mediated effects.
Losartan Potassium is also used in the management of hypertension in certain patients with type 2 diabetes and diabetic nephropathy, and for reducing the risk of stroke in selected patients with hypertension and left ventricular hypertrophy.
Losartan Potassium is an established cardiovascular pharmaceutical API used in the manufacture of tablets and other oral dosage forms.
Important quality attributes include identity, assay, related substances, water content, residue on ignition, specific optical rotation where applicable, residual solvents and elemental impurities.
CAS Number: 124750-99-8
Molecular Formula: C22H23ClN6O·K
Molecular Weight: 461.00 g/mol
Synonym: Losartan Potassium
Drug Class: Angiotensin II Receptor Blocker
Therapeutic Class: Antihypertensive Agent
Therapeutic Area: Cardiovascular / Renal
Molecule Type: Synthetic Small Molecule
Losartan selectively antagonizes the angiotensin II type 1 (AT1) receptor.
AT1 receptor blockade results in:
Unlike ACE inhibitors, Losartan does not directly inhibit ACE and therefore does not inhibit the breakdown of bradykinin.
Losartan Potassium API is used in formulations for:
Losartan Potassium is particularly important in the development of oral antihypertensive formulations. Its selective AT1 receptor antagonism makes it a widely used member of the ARB drug class.
Losartan Potassium is generally described as a white to off-white crystalline powder. It is soluble in water and exhibits physicochemical characteristics suitable for pharmaceutical formulation.
A controlled Losartan Potassium API manufacturing process may involve:
Typical Losartan Potassium API testing may include:
Store Losartan Potassium API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage requirements should follow validated stability data and the manufacturer's approved specification.
Losartan Potassium is relevant to research involving:
Losartan Potassium is an angiotensin II receptor blocker (ARB) API with CAS Number 124750-99-8, molecular formula C22H23ClN6O·K, and molecular weight approximately 461.00 g/mol. It selectively blocks AT1 receptors and is widely used in antihypertensive and cardiovascular pharmaceutical formulations.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 7.0 – 9.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |