Lofexidine is a centrally acting alpha-2 adrenergic receptor agonist used as an active pharmaceutical ingredient in medicines for managing symptoms associated with opioid withdrawal. It is a synthetic imidazoline derivative that acts on central adrenergic receptors.
Lofexidine has the CAS Number 31036-80-3, molecular formula C11H12Cl2N2O and molecular weight 259.13 g/mol. It is commonly formulated as lofexidine hydrochloride for pharmaceutical use.
Lofexidine is a non-opioid, centrally acting alpha-2 adrenergic receptor agonist. It reduces sympathetic nervous system activity and can help manage physical symptoms that occur during acute opioid withdrawal.
Lofexidine is a chemically defined small-molecule pharmaceutical compound. Its chemical identity, purity and quality characteristics are important for pharmaceutical manufacturing and formulation development.
Lofexidine activates alpha-2 adrenergic receptors in the central nervous system. This reduces sympathetic nerve activity and may help decrease autonomic symptoms associated with opioid withdrawal.
Lofexidine can be characterized using validated chromatographic and spectroscopic analytical methods. HPLC may be used for assay and related-substance determination, while suitable spectroscopic and chromatographic techniques can be used for identity testing.
Quality control may include identity, assay, related substances, water content, residual solvents, elemental impurities and other applicable parameters according to the approved product specification.
Lofexidine should be stored in a tightly closed container under controlled pharmaceutical storage conditions. The material should be protected from excessive heat, moisture, direct light and contamination. Specific storage requirements should follow the applicable product specification and Certificate of Analysis.
Lofexidine API may be supplied for pharmaceutical manufacturing, formulation development, analytical testing, neuropharmacology research and other qualified applications. Product specifications, Certificate of Analysis, packaging configuration and regulatory documentation should be confirmed according to the intended application.
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of Lofexidine API for qualified pharmaceutical and research requirements. Customers can request product specifications, analytical documentation, Certificate of Analysis, packaging information and commercial details.
For Lofexidine API requirements in India, contact Swapproop Drugs and Pharmaceuticals for product availability and technical information.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |