Lodoxamide is a mast-cell stabilizer used primarily as an ophthalmic antiallergic agent. It inhibits the release of inflammatory mediators from mast cells and is used in the management of allergic eye conditions, including vernal keratoconjunctivitis.
Lodoxamide is particularly associated with stabilizing mast-cell membranes and preventing the release of histamine and other inflammatory mediators involved in ocular allergic responses.
Lodoxamide is a specialized ophthalmic pharmaceutical API used in the development and manufacture of antiallergic eye-drop formulations.
Important quality attributes include identity, assay, related substances, water content, residue on ignition, heavy metals, residual solvents and particle characteristics.
CAS Number: 53866-97-0
Molecular Formula: C11H6ClN3O2
Molecular Weight: 247.64 g/mol
Chemical Name: N-(3,4-dichlorophenyl)-N′-[2-(2,4-dioxo-1,3-imidazolidinyl)ethyl]oxamide
Drug Class: Mast Cell Stabilizer
Therapeutic Class: Ophthalmic Antiallergic
Therapeutic Area: Ophthalmology / Allergy
Molecule Type: Synthetic Small Molecule
Lodoxamide acts primarily as a mast-cell stabilizer. It inhibits antigen-induced mast-cell degranulation and reduces the release of inflammatory mediators involved in allergic reactions.
By limiting mediator release, Lodoxamide helps reduce ocular manifestations associated with allergic inflammation.
Lodoxamide API is used in pharmaceutical formulations for:
Lodoxamide is formulated as an ophthalmic solution for topical administration to the eye. Its mast-cell-stabilizing properties make it useful for controlling allergic ocular symptoms.
Lodoxamide is a white to off-white crystalline solid/powder. It has limited aqueous solubility, and pharmaceutical formulations use appropriate formulation techniques to achieve the required concentration and stability.
A controlled Lodoxamide API manufacturing process may involve:
Typical Lodoxamide API testing may include:
Store Lodoxamide API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage conditions should follow validated stability data.
Lodoxamide is relevant to research involving:
Lodoxamide is a mast-cell stabilizing ophthalmic API with CAS Number 53866-97-0, molecular formula C11H6ClN3O2, and molecular weight 247.64 g/mol. It is primarily associated with ophthalmic antiallergic formulations and works by inhibiting mast-cell mediator release.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |