Lincomycin Hydrochloride is the hydrochloride salt of lincomycin, a lincosamide antibiotic produced by Streptomyces lincolnensis. It exhibits antibacterial activity primarily by inhibiting bacterial protein synthesis through binding to the 50S subunit of bacterial ribosomes.
Lincomycin Hydrochloride is used in pharmaceutical formulations for the treatment of susceptible Gram-positive bacterial infections and is particularly associated with infections caused by susceptible staphylococci and streptococci.
Lincomycin Hydrochloride is a specialized antibiotic pharmaceutical API requiring controlled fermentation or biotechnological production, purification, salt formation and comprehensive quality testing.
Important quality attributes include identity, assay, related substances, water content, pH, specific optical rotation, residual solvents and microbiological quality.
CAS Number: 859-18-7
Molecular Formula: C18H35ClN2O6S
Molecular Weight: 443.00 g/mol
Drug Class: Antibiotic
Pharmacological Class: Lincosamide Antibiotic
Therapeutic Class: Antibacterial Agent
Therapeutic Area: Infectious Diseases
Molecule Type: Natural Product / Antibiotic
Lincomycin binds to the 50S ribosomal subunit of susceptible bacteria and inhibits bacterial protein synthesis.
This interference with protein synthesis suppresses bacterial growth and produces primarily bacteriostatic activity, although activity may be bactericidal against certain organisms at appropriate concentrations.
Lincomycin Hydrochloride is used for susceptible bacterial infections, including infections associated with:
Use depends on the susceptibility of the causative organism and applicable prescribing information.
Lincomycin belongs to the lincosamide class of antibiotics. It is structurally distinct from β-lactam antibiotics and acts primarily by interfering with bacterial ribosomal protein synthesis.
Lincomycin Hydrochloride is generally produced using a controlled fermentation-based manufacturing process, followed by downstream purification and conversion to the hydrochloride salt.
A typical process may involve:
Typical Lincomycin Hydrochloride API testing may include:
Store Lincomycin Hydrochloride in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage conditions should follow the approved API specification and validated stability data.
Lincomycin Hydrochloride is relevant to research involving:
Lincomycin Hydrochloride is a lincosamide antibiotic API with CAS Number 859-18-7, molecular formula C18H35ClN2O6S, and molecular weight 443.00 g/mol. It acts primarily by binding to the bacterial 50S ribosomal subunit and inhibiting protein synthesis.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 85.0% on anhydrous basis |
| Loss on Drying | NMT 5.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 3.0 – 5.5 |
| Individual Impurity | NMT 2.0% |
| Total Impurities | NMT 5.0% |
| Water Content | NMT 5.0% |