Lincomycin is a naturally derived lincosamide antibiotic active pharmaceutical ingredient (API) with antibacterial activity against a range of susceptible Gram-positive bacteria and certain anaerobic organisms. It is produced by fermentation of Streptomyces lincolnensis and belongs to the lincosamide class of antibacterial compounds.
Lincomycin has the CAS Number 154-21-2, molecular formula C18H34N2O6S and molecular weight 406.54 g/mol. Lincomycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit and interfering with peptide bond formation.
Lincomycin is a lincosamide antibiotic structurally characterized by a pyrrolidine-containing amino acid portion linked to a sulfur-containing sugar moiety. Its antibacterial activity results from inhibition of bacterial protein synthesis.
Lincomycin is closely related pharmacologically to clindamycin, which is a semisynthetic derivative of lincomycin. Pharmaceutical formulations commonly use lincomycin hydrochloride rather than the parent free-base compound.
Lincomycin inhibits bacterial protein synthesis by binding to the 50S subunit of susceptible bacterial ribosomes. This interaction interferes with peptide bond formation and suppresses bacterial protein synthesis, contributing to its antibacterial activity.
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of Lincomycin API for qualified pharmaceutical requirements. The API can be evaluated according to applicable customer specifications and validated quality-control requirements.
For Lincomycin API availability, technical documentation, specifications and commercial requirements, contact Swapproop Drugs and Pharmaceuticals.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |