Lifitegrast is a small-molecule lymphocyte function-associated antigen-1 (LFA-1) antagonist used in ophthalmic pharmaceutical formulations for the treatment of signs and symptoms of dry eye disease. It is a tetrahydroisoquinoline derivative that targets the LFA-1/ICAM-1 inflammatory pathway.
Lifitegrast has the CAS Number 1025967-78-5, molecular formula C29H24Cl2N2O7S and molecular weight 615.48 g/mol. It is supplied as a white to off-white solid or powder and is practically insoluble in water.
Lifitegrast is a selective antagonist of lymphocyte function-associated antigen-1 (LFA-1), an integrin expressed on leukocytes. By binding to LFA-1, lifitegrast blocks its interaction with intercellular adhesion molecule-1 (ICAM-1), a pathway involved in T-cell-mediated inflammation.
Lifitegrast is used as an active pharmaceutical ingredient in ophthalmic drug development and is associated with the treatment of dry eye disease. The API has a defined stereochemical configuration and is characterized by its chemical purity, identity and physical properties.
Lifitegrast binds to lymphocyte function-associated antigen-1 (LFA-1) on leukocytes and inhibits its interaction with intercellular adhesion molecule-1 (ICAM-1). This can interfere with T-cell adhesion, activation and migration and reduce inflammatory signaling associated with dry eye disease.
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of Lifitegrast API for qualified pharmaceutical and research requirements. The product can be evaluated according to applicable customer specifications and validated quality-control requirements.
For Lifitegrast API availability, technical documentation, specifications and commercial requirements, contact Swapproop Drugs and Pharmaceuticals.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 99.0% on dried substance basis |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |