Latanoprostene Bunod is a nitric oxide (NO)-donating prostaglandin F2α analogue used in ophthalmology to reduce elevated intraocular pressure. It is a prodrug that is metabolized to latanoprost acid and a nitric oxide-donating moiety.
Its dual mechanism increases aqueous humor outflow through both the uveoscleral pathway and the trabecular meshwork/Schlemm's canal pathway, helping lower intraocular pressure.
Latanoprostene Bunod is a specialized ophthalmic pharmaceutical API requiring controlled synthesis, purification and stereochemical characterization.
Important quality attributes include identity, assay, related substances, stereochemical purity, water content, residual solvents, elemental impurities, impurity profile and stability.
CAS Number: 860005-32-5
Molecular Formula: C27H39NO6
Molecular Weight: 473.61 g/mol
Drug Class: Prostaglandin Analogue
Pharmacological Class: Prostaglandin F2α Analogue / Nitric Oxide Donor
Therapeutic Class: Antiglaucoma Agent
Therapeutic Area: Ophthalmology
Latanoprostene Bunod is hydrolyzed to latanoprost acid, which activates FP prostanoid receptors and increases uveoscleral outflow.
It also releases nitric oxide, which contributes to relaxation of the trabecular meshwork and increases conventional aqueous humor outflow.
The combined mechanism results in:
Latanoprostene Bunod is used for the reduction of elevated intraocular pressure in patients with:
The specific approved indications depend on the applicable regulatory labeling.
Latanoprostene Bunod is distinctive among prostaglandin analogues because it combines:
Prostaglandin pathway → increased uveoscleral outflow
Nitric oxide pathway → increased conventional/trabecular outflow
This dual activity provides a pharmacological approach to lowering intraocular pressure through multiple aqueous humor drainage pathways.
Typical manufacture may involve:
Latanoprostene Bunod API quality evaluation may include:
Latanoprostene Bunod should be stored according to validated stability data and approved product requirements, with appropriate protection from heat, moisture, oxygen and light.
Latanoprostene Bunod is relevant to research involving:
Latanoprostene Bunod is a nitric oxide-donating prostaglandin analogue with CAS Number 860005-32-5, molecular formula C27H39NO6, and molecular weight 473.61 g/mol. It reduces intraocular pressure through a dual mechanism involving increased uveoscleral and conventional aqueous humor outflow.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |