Latanoprost (Isopropyl Ester) is a prostaglandin F2α analogue and ophthalmic active pharmaceutical ingredient used to reduce elevated intraocular pressure. It is a lipophilic ester prodrug that is converted in the eye to its biologically active form, latanoprost acid.
Latanoprost increases uveoscleral outflow of aqueous humor, resulting in a reduction in intraocular pressure (IOP). It is primarily associated with the treatment of open-angle glaucoma and ocular hypertension.
Latanoprost is the isopropyl ester of a prostaglandin F2α analogue. It has the molecular formula C26H40O5 and a molecular weight of approximately 432.60 g/mol. The CAS Number is 130209-82-4.
Latanoprost is a lipophilic compound, an important characteristic for its penetration through the cornea following topical ophthalmic administration.
Following topical administration, Latanoprost is hydrolyzed by esterases in the cornea to form latanoprost acid, its active metabolite.
Latanoprost acid is a selective agonist of the FP prostanoid receptor. Activation of this receptor increases uveoscleral outflow of aqueous humor, thereby lowering intraocular pressure.
Latanoprost is used in ophthalmic formulations for the reduction of elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension.
It is commonly formulated as an ophthalmic solution intended for topical administration to the eye.
Latanoprost API can be evaluated using validated analytical procedures for identification, assay, related substances, water content, residual solvents, elemental impurities and other applicable quality attributes.
Because Latanoprost contains multiple stereochemical centers and is intended for ophthalmic pharmaceutical applications, control of identity, stereochemical purity, chemical purity and degradation products is particularly important.
HPLC and suitable spectroscopic and chromatographic techniques may be used for identity, assay and purity testing. Acceptance criteria should be based on the applicable pharmacopoeial monograph, approved manufacturer's specification and Certificate of Analysis.
Latanoprost should be stored under controlled pharmaceutical conditions in a tightly closed container and protected from excessive heat, moisture, light and contamination. Temperature requirements should follow the approved manufacturer's specification because the compound can be sensitive to environmental conditions.
Latanoprost API may be supplied for qualified pharmaceutical manufacturing, ophthalmic formulation development, research and analytical applications. Product specifications, Certificate of Analysis, packaging details and regulatory documentation should be confirmed according to the intended application.
Latanoprost (Isopropyl Ester) API is available for pharmaceutical development and manufacturing requirements subject to applicable quality and regulatory requirements. Customers can request product specifications, analytical documentation, Certificate of Analysis, packaging information and commercial details for their specific requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 2.0% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |