Latanoprost (Free Acid Form) is the active acid form of latanoprost, a synthetic prostaglandin F2α analogue used primarily in ophthalmology. Latanoprost itself is administered as an ester prodrug and is hydrolyzed in ocular tissues to the biologically active free acid.
The active free acid acts primarily on FP prostanoid receptors, increasing aqueous humor outflow through the uveoscleral pathway and thereby reducing intraocular pressure.
Latanoprost Free Acid is a specialized ophthalmic pharmaceutical ingredient requiring controlled synthesis, purification and stereochemical characterization.
Important quality attributes include identity, assay, related substances, stereochemical purity, water content, residual solvents, elemental impurities and stability.
CAS Number: 41639-83-2
Molecular Formula: C23H32O5
Molecular Weight: 388.50 g/mol
Drug Class: Prostaglandin Analogue
Pharmacological Class: Prostaglandin F2α Analogue
Therapeutic Class: Antiglaucoma Agent
Therapeutic Area: Ophthalmology
The latanoprost free acid is a potent FP prostanoid receptor agonist.
Activation of FP receptors increases aqueous humor drainage, particularly through the uveoscleral outflow pathway.
This results in:
Latanoprost is primarily used in ophthalmic formulations for:
The free acid is the pharmacologically active species generated from latanoprost following hydrolysis.
Latanoprost is a lipid-soluble ester prodrug designed to improve ocular penetration. Following administration, it is hydrolyzed by esterases to latanoprost free acid, which binds to FP receptors.
This prodrug-to-active-metabolite conversion is an important characteristic of the latanoprost pharmacological profile.
Typical manufacture may involve:
Latanoprost Free Acid API quality evaluation may include:
Latanoprost Free Acid should be stored according to validated stability data and approved product requirements, with appropriate protection from heat, moisture, oxygen and light. Prostaglandin analogues can be sensitive to environmental conditions, making controlled storage important.
Latanoprost Free Acid is relevant to research involving:
Latanoprost (Free Acid Form) is the pharmacologically active acid form of latanoprost, with CAS Number 41639-83-2, molecular formula C23H32O5, and molecular weight 388.50 g/mol. It acts as an FP receptor agonist and increases uveoscleral aqueous humor outflow, making it relevant to the treatment of elevated intraocular pressure.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |