Lasmiditan is a selective serotonin 5-HT1F receptor agonist developed for the acute treatment of migraine with or without aura. It belongs to the ditan class of antimigraine medicines and differs from triptans because its mechanism does not primarily depend on 5-HT1B-mediated cerebral vasoconstriction.
Lasmiditan acts on 5-HT1F receptors involved in migraine-related trigeminal signaling and helps reduce migraine-associated symptoms.
Lasmiditan is a specialized neurology and antimigraine pharmaceutical API manufactured through controlled chemical synthesis, purification and crystallization.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities, polymorphic form and stability.
CAS Number: 439239-90-4
Molecular Formula: C26H19F2N3O2
Molecular Weight: 439.45 g/mol
Drug Class: Antimigraine Agent
Pharmacological Class: Selective 5-HT1F Receptor Agonist
Therapeutic Class: Antimigraine / Neurology
Therapeutic Area: Neurology
Lasmiditan selectively activates 5-HT1F serotonin receptors.
Activation of these receptors is thought to inhibit migraine-associated trigeminal pathways and reduce neuropeptide release involved in migraine signaling.
Its pharmacological activity includes:
Unlike triptans, lasmiditan does not rely on 5-HT1B-mediated vasoconstriction for its antimigraine effect.
Lasmiditan is used for the acute treatment of migraine attacks with or without aura in adults.
It is intended for treatment of an acute migraine episode rather than preventive migraine therapy.
Lasmiditan is the first member of the ditan class of migraine therapies. Its selective 5-HT1F mechanism provides an alternative approach to migraine treatment for patients for whom vasoconstrictive mechanisms associated with some older antimigraine medicines may be a concern.
Typical API manufacturing may involve:
Lasmiditan API quality evaluation may include:
Lasmiditan should be stored in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage conditions should be established through validated stability studies.
Lasmiditan is relevant to research involving:
Lasmiditan is a selective 5-HT1F receptor agonist with CAS Number 439239-90-4, molecular formula C26H19F2N3O2, and molecular weight 439.45 g/mol. It is an orally active ditan-class antimigraine agent used for the acute treatment of migraine with or without aura.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |