Ketorolac Trometamol is the tromethamine salt of ketorolac, a non-steroidal anti-inflammatory drug (NSAID) with potent analgesic activity. It is primarily used for the short-term management of moderately severe acute pain.
Ketorolac works mainly by inhibiting cyclooxygenase (COX) enzymes, reducing the synthesis of prostaglandins involved in pain and inflammation.
Ketorolac Trometamol is a specialized analgesic and anti-inflammatory pharmaceutical API manufactured through controlled chemical synthesis and salt formation.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities, optical purity and stability.
CAS Number: 74103-06-3
Molecular Formula: C15H13NO3·C4H11NO3
Molecular Weight: 376.41 g/mol
Drug Class: Non-Steroidal Anti-Inflammatory Drug (NSAID)
Pharmacological Class: Pyrrolo-pyrrole NSAID
Therapeutic Class: Analgesic / Anti-inflammatory
Therapeutic Area: Pain Management
Ketorolac inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis.
Reduced prostaglandin production decreases:
Ketorolac has strong analgesic activity relative to its anti-inflammatory effects.
Ketorolac Trometamol is used primarily for:
The route, duration and approved indications depend on the specific formulation and regulatory labeling.
Ketorolac is a non-opioid analgesic. Unlike opioid analgesics, its analgesic activity is primarily mediated through inhibition of prostaglandin synthesis.
Because of its safety profile, systemic ketorolac is generally intended for short-term use rather than long-term chronic pain management.
Typical API manufacturing may involve:
Ketorolac Trometamol API quality evaluation may include:
Ketorolac Trometamol should be stored in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage conditions should be established through validated stability studies.
Ketorolac Trometamol is relevant to research involving:
Ketorolac Trometamol is a tromethamine salt of ketorolac, with CAS Number 74103-06-3, molecular formula C15H13NO3·C4H11NO3, and molecular weight 376.41 g/mol. It is a potent NSAID analgesic primarily used for short-term treatment of moderate to severe acute pain.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms by IR and HPLC |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |