Ketanserin is a selective serotonin 5-HT2A receptor antagonist that has been studied for its effects on vascular tone, platelet function and serotonin-mediated responses. It belongs to the quinazoline derivative class and has been investigated primarily in cardiovascular and vascular pharmacology.
Ketanserin inhibits serotonin-mediated vasoconstriction and can influence vascular smooth-muscle activity.
Ketanserin is a specialized cardiovascular and pharmacological research API manufactured through controlled chemical synthesis, purification and crystallization.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities, residue on ignition and stability.
CAS Number: 74050-98-9
Molecular Formula: C22H22F3N3O2
Molecular Weight: 417.43 g/mol
Drug Class: Serotonin Receptor Antagonist
Pharmacological Class: 5-HT2A Receptor Antagonist
Therapeutic Class: Cardiovascular / Vascular Pharmacology
Therapeutic Area: Cardiovascular Research
Ketanserin primarily blocks 5-HT2A serotonin receptors.
This reduces serotonin-mediated effects on vascular smooth muscle and platelets and may result in:
Ketanserin also has some affinity for α1-adrenergic receptors, which can contribute to its pharmacological profile.
Ketanserin has been investigated for:
Its clinical use and regulatory status vary by jurisdiction.
Ketanserin is particularly useful as a pharmacological tool for studying 5-HT2A receptor-mediated signaling.
The 5-HT2A receptor is involved in vascular smooth-muscle contraction, platelet responses and several central and peripheral serotonin-mediated processes.
Typical API manufacturing may involve:
Ketanserin API quality evaluation may include:
Ketanserin should be stored in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive heat, moisture and direct light. Final storage conditions should be established through validated stability studies.
Ketanserin is relevant to research involving:
Ketanserin is a 5-HT2A serotonin receptor antagonist with CAS Number 74050-98-9, molecular formula C22H22F3N3O2, and molecular weight 417.43 g/mol. It inhibits serotonin-mediated vascular responses and has been studied extensively in cardiovascular and serotonin-receptor pharmacology.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |