Isradipine is a dihydropyridine calcium channel blocker (CCB) used primarily as an antihypertensive agent. It selectively inhibits L-type calcium channels in vascular smooth muscle, producing arterial vasodilation and a reduction in peripheral vascular resistance.
Isradipine is administered orally and is primarily associated with the treatment of hypertension.
Isradipine is a specialized cardiovascular pharmaceutical API manufactured through controlled chemical synthesis, purification and crystallization.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities, dissolution-related properties and stability.
CAS Number: 75695-93-1
Molecular Formula: C23H21N3O5
Molecular Weight: 419.44 g/mol
Drug Class: Calcium Channel Blocker
Pharmacological Class: Dihydropyridine Calcium Channel Blocker
Therapeutic Class: Antihypertensive
Therapeutic Area: Cardiology
Isradipine inhibits the influx of calcium ions through L-type voltage-dependent calcium channels, particularly in vascular smooth muscle.
This produces:
Its vascular selectivity is responsible for its principal antihypertensive effect.
Isradipine is primarily used for:
Its approved indications can vary according to the regulatory jurisdiction and formulation.
Isradipine belongs to the 1,4-dihydropyridine class of calcium channel blockers. Like other members of this class, its principal pharmacological effect is relaxation of arterial vascular smooth muscle.
The reduction in peripheral vascular resistance contributes to its antihypertensive activity.
Typical API manufacturing may involve:
Isradipine API quality evaluation may include:
Isradipine should be stored in a tightly closed container under controlled pharmaceutical conditions, protected from excessive heat, moisture and direct light. Final storage conditions should be established from validated stability studies.
Isradipine is relevant to research involving:
Isradipine is a dihydropyridine L-type calcium channel blocker with CAS Number 75695-93-1, molecular formula C23H21N3O5, and molecular weight 419.44 g/mol. It produces arterial vasodilation by inhibiting L-type calcium channels and is primarily used as an antihypertensive agent.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 4.0 – 7.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |