Isoproterenol Hydrochloride is the hydrochloride salt of isoproterenol, also known as isoprenaline. It is a synthetic sympathomimetic catecholamine and a non-selective beta-adrenergic receptor agonist. The compound primarily stimulates beta-1 and beta-2 adrenergic receptors and produces characteristic cardiovascular and smooth-muscle effects.
Isoproterenol Hydrochloride is used as a pharmaceutical active ingredient in preparations intended for specific cardiovascular applications. It produces positive chronotropic and inotropic effects on the heart and can also cause relaxation of bronchial smooth muscle through beta-2 adrenergic receptor stimulation.
Isoproterenol Hydrochloride is identified by CAS Number 51-30-9. It has the molecular formula C11H18ClNO3 and a molecular weight of approximately 247.72 g/mol. The compound is the hydrochloride salt of isoproterenol and is generally supplied as a crystalline pharmaceutical substance.
Isoproterenol Hydrochloride contains a catecholamine structure with two phenolic hydroxyl groups, a secondary alcohol and an isopropyl-substituted amino group. Formation of the hydrochloride salt provides the protonated amine together with chloride as the counterion.
Isoproterenol Hydrochloride is a non-selective beta-adrenergic receptor agonist. It stimulates beta-1 adrenergic receptors in cardiac tissue, increasing heart rate and myocardial contractility. Stimulation of beta-2 adrenergic receptors produces relaxation of bronchial smooth muscle and other smooth muscles.
Isoproterenol Hydrochloride is used in selected cardiovascular applications requiring beta-adrenergic stimulation. Pharmaceutical preparations may be used for temporary management of certain forms of bradycardia and heart block under appropriate medical supervision. Because it stimulates beta-2 receptors, the compound has also historically been used as a bronchodilator.
Pharmaceutical Isoproterenol Hydrochloride can be characterized using validated chromatographic and spectroscopic analytical methods. HPLC may be used for assay and related-substance determination, while identity can be confirmed using suitable chromatographic, spectroscopic and chemical identification procedures.
Quality control should include identity, assay, related substances, water content, residual solvents, elemental impurities and other applicable parameters according to the approved drug-substance specification.
Isoproterenol Hydrochloride should be stored in a tightly closed container under controlled pharmaceutical storage conditions. The material should be protected from excessive heat, moisture and contamination. Because catecholamine compounds may be susceptible to oxidation, appropriate packaging and handling conditions should be maintained.
Isoproterenol Hydrochloride API may be supplied for pharmaceutical manufacturing, formulation development, analytical testing and other qualified pharmaceutical applications. Product specifications, Certificate of Analysis, packaging configuration and regulatory documentation should be confirmed according to the intended application.
For Isoproterenol Hydrochloride API requirements, customers can request product specifications, analytical documentation, Certificate of Analysis, packaging information and commercial details. Quality parameters should be evaluated against the applicable pharmaceutical specification before procurement.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 170–175°C |