Isoproterenol Hydrochloride (Isoproterenol HCl) is a synthetic sympathomimetic amine and non-selective beta-adrenergic receptor agonist. It produces pronounced stimulation of β₁ and β₂ adrenergic receptors, resulting in increased cardiac activity and relaxation of bronchial smooth muscle.
It is primarily used as a cardiovascular agent in controlled clinical settings and may be administered as an intravenous infusion or by other parenteral routes depending on the approved formulation.
Isoproterenol HCl is a specialized adrenergic pharmaceutical API manufactured through controlled chemical synthesis, purification and salt formation.
Critical quality attributes include identity, assay, related substances, water content, residual solvents, optical purity where applicable, chloride content and stability.
CAS Number: 51-30-9
Molecular Formula: C11H17NO3·HCl
Molecular Weight: 247.72 g/mol
Drug Class: Adrenergic Agonist
Pharmacological Class: Non-Selective Beta-Adrenergic Agonist
Therapeutic Class: Cardiovascular Agent
Therapeutic Area: Cardiology / Emergency Medicine
Isoproterenol stimulates β₁- and β₂-adrenergic receptors.
β₁-receptor stimulation increases cardiac:
β₂-receptor stimulation promotes:
The overall pharmacological effect is therefore predominantly positive chronotropic and inotropic cardiac activity with bronchodilation.
Isoproterenol HCl has clinical applications in selected cardiovascular situations, including:
Its use depends on the approved formulation and applicable clinical guidelines.
Isoproterenol differs from selective β₁ agonists because it activates both β₁ and β₂ receptors. Its pharmacological activity can therefore produce substantial increases in heart rate and contractility while also causing peripheral vasodilation.
Typical API manufacturing may involve:
Isoproterenol HCl API quality evaluation may include:
Isoproterenol HCl should be stored in a tightly closed container under controlled pharmaceutical conditions, protected from excessive heat, moisture and light. Because catechol-containing compounds can be susceptible to oxidation, appropriate environmental and packaging controls are important.
Isoproterenol HCl is relevant to research involving:
Isoproterenol HCl is a non-selective β-adrenergic receptor agonist with CAS Number 51-30-9, molecular formula C11H17NO3·HCl, and molecular weight 247.72 g/mol. It stimulates β₁ and β₂ receptors and is primarily associated with cardiovascular applications requiring controlled adrenergic stimulation.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 2.0% |