Isoflurane is a halogenated volatile inhalational anesthetic used for the induction and maintenance of general anesthesia. It is a fluorinated ether supplied as a volatile liquid for administration through an anesthesia vaporizer.
Isoflurane produces reversible central nervous system depression and is widely used in operating-room and anesthetic settings.
Isoflurane is a specialized volatile anesthetic pharmaceutical ingredient requiring controlled manufacturing, purification and packaging because of its volatility and sensitivity to contamination.
Quality control focuses on identity, assay, related substances, water content, acidity, non-volatile residue and other physicochemical characteristics relevant to inhalational anesthetic quality.
CAS Number: 26675-46-7
Molecular Formula: C3H2ClF5O
Molecular Weight: 184.49 g/mol
Drug Class: General Anesthetic
Pharmacological Class: Volatile Inhalational Anesthetic
Therapeutic Class: Anesthetic Agent
Therapeutic Area: Anesthesiology
Isoflurane produces general anesthesia by acting on multiple molecular targets within the central nervous system. Its effects involve modulation of several ion channels and neurotransmitter systems, resulting in reduced neuronal excitability and reversible loss of consciousness.
The clinical effects include:
Isoflurane is primarily used for:
Isoflurane is a clear, colorless, volatile liquid with a characteristic ether-like odor. It is nonflammable under ordinary clinical conditions and has a relatively low blood-gas solubility, supporting comparatively rapid changes in anesthetic depth.
Typical production may involve:
Isoflurane quality evaluation may include:
Isoflurane should be stored in tightly closed, appropriately labeled containers, protected from excessive heat and direct light. Because it is a volatile anesthetic, appropriate handling and storage controls should be maintained throughout manufacturing and distribution.
Isoflurane is relevant to research involving:
Isoflurane is a volatile halogenated inhalational anesthetic with CAS Number 26675-46-7, molecular formula C3H2ClF5O, and molecular weight 184.49 g/mol. It is administered through an anesthesia vaporizer for induction and maintenance of general anesthesia.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | ≤0.05% |