Ioflupane is a cocaine analogue radiopharmaceutical ligand used in nuclear medicine for imaging the dopamine transporter (DAT) in the brain. The diagnostic agent is commonly administered as Ioflupane I-123, in which ioflupane is labeled with the radioactive isotope iodine-123.
Ioflupane I-123 SPECT imaging is used as an adjunct in the evaluation of adult patients with suspected Parkinsonian syndromes and essential tremor, helping visualize the integrity of presynaptic dopaminergic neurons.
Ioflupane is a specialized pharmaceutical compound used in the development and manufacture of radiolabeled diagnostic agents. Production requires controlled chemical synthesis, purification and, for the final radiopharmaceutical, radioiodination and radiochemical quality control.
Important quality attributes include identity, chemical purity, radiochemical purity, specific activity, radionuclidic identity, radionuclidic purity and stability.
CAS Number: 83209-65-8
Molecular Formula: C19H26F2INO2
Molecular Weight: 453.32 g/mol
Drug Class: Diagnostic Radiopharmaceutical
Pharmacological Class: Dopamine Transporter Ligand
Therapeutic Class: Diagnostic Imaging Agent
Therapeutic Area: Nuclear Medicine / Neurology
Ioflupane binds to the dopamine transporter (DAT) located on presynaptic dopaminergic nerve terminals in the striatum.
When labeled with iodine-123, the radiotracer allows visualization of striatal dopamine transporter distribution using single-photon emission computed tomography (SPECT).
Reduced DAT uptake in the striatum can support the distinction between disorders associated with loss of nigrostriatal dopaminergic neurons and conditions such as essential tremor.
Ioflupane I-123 is used as a diagnostic imaging agent for:
It is a diagnostic agent rather than a therapeutic drug.
The clinically used product contains Ioflupane labeled with iodine-123. Iodine-123 is a gamma-emitting radionuclide suitable for SPECT imaging.
The radiopharmaceutical is designed to reach the brain and bind to dopamine transporters, allowing regional DAT distribution to be assessed through gamma-camera imaging.
Production of Ioflupane-based radiopharmaceutical material may involve:
Ioflupane / Ioflupane I-123 quality evaluation may include:
Ioflupane chemical material should be stored according to its validated stability requirements. Ioflupane I-123 radiopharmaceutical requires controlled radioactive-material storage, appropriate shielding and handling according to applicable radiation-safety regulations.
Ioflupane is relevant to research involving:
Ioflupane is a dopamine transporter ligand with CAS Number 83209-65-8, molecular formula C19H26F2INO2, and molecular weight 453.32 g/mol. Its iodine-123-labeled form is used as a SPECT radiopharmaceutical for visualization of dopamine transporter distribution in the brain.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |