Iodipamide is an iodinated organic compound and ionic dimeric radiographic contrast agent used primarily in diagnostic imaging procedures involving the biliary system. It is also known by the synonym Adipiodone and is chemically classified as a tri-iodinated benzoic acid derivative. Iodipamide is associated with radiographic visualization of the bile ducts and gallbladder during cholangiography and cholecystography procedures.
Iodipamide has the molecular formula C20H14I6N2O6 and a molecular weight of 1139.76 g/mol. Its chemical name is 3-[[6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoic acid. The compound contains six iodine atoms, which provide its radiopacity and make it suitable for use as an X-ray contrast medium.
Iodipamide is identified by CAS Number 606-17-7 and has the molecular formula C20H14I6N2O6. It is described as a white to off-white solid or crystalline powder. Reported physical data include a melting point of approximately 306–308°C with decomposition. The compound is very slightly soluble in water and has limited solubility in common organic solvents. Iodipamide has also been described as practically odorless and as a crystalline powder in pharmacopeial references.
Iodipamide is used as a radiographic contrast agent for diagnostic imaging of the biliary tract. Its iodine content increases X-ray attenuation and improves visualization of anatomical structures during contrast examinations. Iodipamide is particularly associated with cholecystography and intravenous cholangiography.
Iodipamide is also recognized in the United States Pharmacopeia (USP) as a drug substance with an established monograph. The USP monograph specifies an assay range of 98.0% to 102.0% calculated on the anhydrous basis. USP also specifies water content of not more than 1.0% and residue on ignition of not more than 0.1%.
Iodipamide is available as a USP reference standard and is covered by a USP monograph. The USP identification procedures include thin-layer chromatographic identification and a characteristic reaction involving the evolution of violet vapors upon heating. The monograph also includes requirements relating to free aromatic amines, iodine and iodide, water determination, residue on ignition and assay.
For the USP substance, Iodipamide should be preserved in well-closed containers and stored at 25°C, with permitted excursions between 15°C and 30°C. Appropriate protection from moisture and contamination should be maintained during storage and handling.
Iodipamide can be supplied for pharmaceutical and analytical applications according to the applicable quality requirements. Product specifications, analytical documentation, batch information, packaging configuration and regulatory documentation should be confirmed against the applicable batch specification and customer requirements before supply.
For Iodipamide API requirements, buyers can request product specifications, analytical documentation, packaging information and commercial details based on their intended pharmaceutical or research application. Quality parameters should be evaluated against the applicable pharmacopeial or customer-specific specification.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.1% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |