Insulin-Like Growth Factor 1 (IGF-1) is a naturally occurring peptide hormone and growth factor that plays an important role in cell growth, differentiation, metabolism and tissue development. It is primarily produced in the liver in response to growth hormone stimulation and acts through the insulin-like growth factor 1 receptor (IGF-1R).
Recombinant IGF-1 is used in pharmaceutical research, biotechnology and the development of therapeutic products involving growth-factor signaling and endocrine disorders.
Insulin-Like Growth Factor 1 is a specialized recombinant peptide/protein pharmaceutical ingredient produced using biotechnology-based expression and purification processes.
Quality evaluation focuses on critical biological and physicochemical characteristics such as identity, purity, molecular weight, peptide content, aggregation, potency, host-cell impurities, residual DNA and microbial quality.
CAS Number: 67763-96-6
Molecular Formula: C331H512N94O101S7
Molecular Weight: 7649.7 g/mol
Amino Acids: 70
Molecule Type: Recombinant Peptide Hormone / Growth Factor
Drug Class: Growth Factor
Pharmacological Class: Insulin-Like Growth Factor
Therapeutic Area: Endocrinology / Growth Disorders
IGF-1 primarily acts by binding to the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase.
Receptor activation initiates intracellular signaling pathways including:
IGF-1 also has metabolic effects that overlap with insulin signaling.
IGF-1 is an important mediator of the growth hormone–IGF-1 axis. It contributes to:
Circulating IGF-1 levels are influenced by growth hormone, nutritional status, age and several physiological factors.
Recombinant IGF-1 has pharmaceutical relevance in:
Recombinant human IGF-1 has also been developed for specific clinical applications involving severe primary IGF-1 deficiency, subject to applicable regulatory approvals.
Commercial recombinant IGF-1 is produced using recombinant DNA technology. Manufacturing generally involves:
IGF-1 quality evaluation may include:
Insulin-Like Growth Factor 1 should be stored according to validated stability data and applicable product specifications. Recombinant proteins require appropriate temperature control and protection against conditions that may cause aggregation, degradation or loss of biological activity.
IGF-1 is relevant to research involving:
Insulin-Like Growth Factor 1 is a 70-amino-acid recombinant peptide hormone with CAS Number 67763-96-6 and molecular weight of approximately 7.65 kDa. It mediates important effects on growth, cellular proliferation and metabolism primarily through activation of the IGF-1 receptor.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |