Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS) is a functional cellulose-derived pharmaceutical excipient widely used in advanced oral drug-delivery and pharmaceutical formulation systems. HPMCAS is a modified cellulose polymer containing hydroxypropoxy, methoxy, acetate, and succinate substituents.
HPMCAS is particularly valuable for formulations containing poorly water-soluble active pharmaceutical ingredients (APIs). Its pH-dependent solubility and enteric properties make it suitable for enteric coating, solid dispersion, amorphous solid dispersion (ASD), and other drug-solubilization technologies.
Swapnroop Pharma manufactures and supplies Hydroxypropyl Methylcellulose Acetate Succinate in India for pharmaceutical formulation, drug-development, and bulk excipient requirements. Different HPMCAS grades can be selected according to substitution profile, particle characteristics, viscosity, and intended pharmaceutical application.
Hydroxypropyl Methylcellulose Acetate Succinate is used in:
One of the important applications of HPMCAS is its use as a polymeric carrier in amorphous solid dispersion technology. It can help maintain an API in an amorphous state and inhibit drug recrystallization, supporting improved apparent solubility and dissolution performance for suitable poorly soluble compounds.
HPMCAS is commonly considered when formulation developers require a polymer with both drug-polymer interaction and pH-dependent dissolution characteristics.
HPMCAS has pH-dependent solubility and can be used in enteric and delayed-release pharmaceutical formulations. Its acidic substituent groups contribute to dissolution behavior at higher intestinal pH, while the polymer remains less soluble under acidic gastric conditions.
The appropriate grade should be selected according to the desired dissolution profile, formulation process, API characteristics, and applicable regulatory requirements.
HPMCAS is a semi-synthetic cellulose derivative. It is produced by chemically modifying cellulose with methoxy, hydroxypropoxy, acetyl, and succinoyl groups.
Because HPMCAS is a substituted polymer, its properties are not represented by one simple fixed molecular formula or molecular weight. Substitution levels, viscosity, particle size, and grade characteristics influence its functionality in pharmaceutical formulations.
Pharmaceutical-grade HPMCAS should be tested according to the applicable product specification and pharmacopoeial requirements. Typical quality parameters include:
Exact acceptance limits are grade-specific and should be confirmed against the approved specification and batch CoA.
Swapnroop Pharma provides Hydroxypropyl Methylcellulose Acetate Succinate manufacturing and supply solutions in India for pharmaceutical companies and formulation developers.
Our HPMCAS supply can support applications involving amorphous solid dispersions, hot-melt extrusion, enteric coatings, delayed-release dosage forms, and poorly soluble API formulation development.
The material can be supplied according to agreed pharmaceutical-grade specifications, packaging requirements, documentation requirements, and customer quality standards.
HPMCAS should be stored in tightly closed, suitable moisture-protective packaging in a cool, dry and clean environment. The material should be protected from excessive moisture, contamination, heat, and direct sunlight.
Storage conditions should always follow the applicable product specification, CoA, SDS, and manufacturer's recommendations.
Depending on grade and customer requirements, documentation can include:
Swapnroop Pharma supplies Hydroxypropyl Methylcellulose Acetate Succinate as a specialized pharmaceutical excipient and functional polymer for modern oral drug-delivery and pharmaceutical formulation applications.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |