Hydroxyprogesterone Caproate is a synthetic progestogen and ester derivative of hydroxyprogesterone. It is a steroidal active pharmaceutical ingredient that produces progestational activity by interacting with progesterone receptors.
Hydroxyprogesterone Caproate has the molecular formula C27H40O4 and a molecular weight of 428.61 g/mol. Its CAS Number is 630-56-8.
Hydroxyprogesterone Caproate is a long-acting ester of hydroxyprogesterone. The caproate ester increases the lipophilicity of the parent steroid and has historically been used in depot formulations designed for prolonged progestogenic activity.
It is relevant to pharmaceutical research, steroidal API development and formulation development.
Hydroxyprogesterone Caproate exerts its effects primarily through progesterone receptors.
Following administration, the compound provides progestational activity that can influence reproductive tissues and progesterone-responsive biological pathways.
Hydroxyprogesterone Caproate API has been used in the development and manufacture of:
Hydroxyprogesterone Caproate is a synthetic steroidal compound manufactured through controlled chemical synthesis and esterification processes, followed by purification, crystallization and drying.
Quality testing may include identity, assay, related substances, water content, residue on ignition, optical rotation and residual solvents according to the applicable approved specification.
Hydroxyprogesterone Caproate is generally supplied as a white or almost white crystalline powder. It is practically insoluble in water and soluble in selected organic solvents.
Hydroxyprogesterone Caproate should be stored in a tightly closed container, protected from excessive moisture, heat and direct light. Storage conditions should follow the manufacturer's current CoA, SDS and validated stability requirements.
Depending on the intended application, documentation may include:
Hydroxyprogesterone Caproate is a synthetic steroidal progestogen with established progestational activity. Its long-acting ester structure and pharmaceutical properties make it relevant to steroidal API research, formulation development and hormonal pharmaceutical applications.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 97.0% – 103.0% |
| Loss on Drying | NMT 1.0% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Specific Rotation | Approximately +50° to +60° |
| Melting Point | Approximately 120–124°C |