Hydrolyzed Sodium Hyaluronate is a lower-molecular-weight derivative of Sodium Hyaluronate produced through controlled hydrolysis of the hyaluronate polymer. It is a specialty cosmetic ingredient used primarily in moisturizing, humectant and skin-conditioning formulations. Its standardized INCI name is HYDROLYZED SODIUM HYALURONATE.
Hydrolysis reduces the molecular size of the original Sodium Hyaluronate polymer, producing material with different molecular-weight and solution characteristics. Commercial grades can range from several kilodaltons to tens of kilodaltons, so the molecular-weight specification is an important part of the product identity. For example, documented cosmetic materials include approximately 3–5 kDa, around 20 kDa and 5–10 kDa grades.
The raw material is generally supplied as a white to off-white powder or granules and is soluble in water. Its lower molecular-weight profile makes it particularly relevant to modern hydration-focused skin-care formulations.
Hydrolyzed Sodium Hyaluronate is a hydrolysate of Sodium Hyaluronate. It retains the fundamental hyaluronate polysaccharide structure based on repeating units of N-acetyl-D-glucosamine and D-glucuronic acid, but the polymer chains have been reduced through hydrolysis.
The commonly used CAS identifier is 9067-32-7, corresponding to the Sodium Hyaluronate polymer family. However, Hydrolyzed Sodium Hyaluronate is not a single discrete small molecule, and regulatory databases may not assign a separate CAS number to every hydrolyzed molecular-weight grade. PubChem specifically treats it as a substance reference rather than a discrete molecular structure.
The commonly represented polymer formula is (C₁₄H₂₀NNaO₁₁)n. Because the material is polymeric and hydrolyzed to a defined molecular-weight distribution, it does not have one fixed molecular weight applicable to every commercial grade.
Hydrolyzed Sodium Hyaluronate is primarily used as a humectant, skin-conditioning and hair-conditioning cosmetic ingredient. Its ability to interact with water makes it valuable in hydration-oriented skin-care formulations.
Molecular weight is an important functional parameter. Lower-molecular-weight hyaluronate fractions have different diffusion, hydration and rheological characteristics from conventional high-molecular-weight Sodium Hyaluronate. Scientific literature describes hydrolyzed hyaluronate as one of the lower-molecular-weight forms obtained by cleavage of the original polymer chains.
The term “hydrolyzed” should not, however, be interpreted as one specific molecular-weight value. A 2 kDa material, a 5–10 kDa material and a 20 kDa material can have different formulation behavior and should be specified separately.
Hydrolyzed Sodium Hyaluronate can be incorporated into a broad range of cosmetic and personal-care formulations, including facial serums, moisturising creams, lotions, gels, essences, masks, eye-care products and other hydration-focused formulations. Commercial materials are documented for use in serums, creams, lotions and gels.
Because it is water soluble, Hydrolyzed Sodium Hyaluronate is suitable for appropriately designed aqueous formulation systems. Controlled dispersion and hydration should be used during manufacturing to obtain consistent incorporation.
Different molecular-weight grades can be selected according to the desired formulation profile. A very-low-molecular-weight grade can behave differently from a 20 kDa or higher grade, particularly with respect to viscosity and solution properties.
Hydrolyzed Sodium Hyaluronate can also be combined with conventional Sodium Hyaluronate or other hyaluronate derivatives to create formulations containing multiple molecular-weight fractions. Published research has evaluated combinations of different molecular-weight hyaluronates in topical formulations.
Molecular-weight range is the most important specification for Hydrolyzed Sodium Hyaluronate. Commercial materials can have substantially different molecular-weight distributions. Examples documented commercially include approximately 3–5 kDa, 5–10 kDa and 5–20 kDa ranges.
The Assay (HPLC) field should not be assigned an arbitrary percentage. As a polymeric ingredient, Hydrolyzed Sodium Hyaluronate is more appropriately characterized using molecular weight, molecular-weight distribution, glucuronic acid content, moisture, pH, ash, protein, viscosity and microbiological parameters according to the grade.
One current commercial specification reports ≥92% content and ≥45% glucuronic acid for a low-molecular-weight cosmetic grade, but these values are supplier-specific and should not be transferred to every Hydrolyzed Sodium Hyaluronate product.
Moisture control is also important because hyaluronate powders can absorb moisture from the environment. The product should therefore be stored in tightly closed packaging under appropriate dry and controlled conditions.
Hydrolyzed Sodium Hyaluronate is a specialty cosmetic ingredient for manufacturers developing advanced moisturizing, hydrating and skin-conditioning products. Controlled hydrolysis provides different molecular-weight grades that can be selected according to formulation requirements.
For B2B cosmetic raw-material sourcing, the specification should clearly identify the INCI name, CAS/family identifier, molecular-weight range, glucuronic acid content, moisture, pH, polymer content, physical appearance and applicable microbiological requirements.
As a Hydrolyzed Sodium Hyaluronate Cosmetic Ingredient Manufacturer in India, the focus is on controlled molecular-weight grades, consistent raw-material quality and suitability for bulk cosmetic and personal-care formulation requirements.
| Parameter | Specification |
|---|---|
| Appearance | White or colourless crystals / white powder |