Hydrocortisone Valerate is a synthetic corticosteroid and ester derivative of hydrocortisone used primarily as a topical anti-inflammatory agent. It belongs to the glucocorticoid class and helps reduce inflammation, redness, itching and other symptoms associated with corticosteroid-responsive skin conditions.
Hydrocortisone Valerate is particularly suitable for topical dermatological formulations, including creams, ointments and lotions.
Hydrocortisone Valerate is a specialized corticosteroid pharmaceutical API requiring controlled steroid synthesis, purification and analytical characterization. Manufacturing and quality control typically focus on chemical identity, assay, related substances, stereochemical purity, residual solvents and degradation products.
CAS Number: 575-90-6
Molecular Formula: C26H36O6
Molecular Weight: 444.57 g/mol
Chemical Name: Hydrocortisone 17-valerate
Drug Class: Corticosteroid
Pharmacological Class: Glucocorticoid
Therapeutic Class: Topical Anti-inflammatory
Therapeutic Area: Dermatology
Hydrocortisone Valerate acts through the glucocorticoid receptor in cells. After receptor binding, the corticosteroid-receptor complex influences gene expression and suppresses multiple inflammatory pathways.
This reduces the production and activity of inflammatory mediators, helping decrease erythema, edema, itching and inflammation in responsive skin conditions.
Hydrocortisone Valerate is used in topical formulations for corticosteroid-responsive dermatological conditions, including:
The specific approved indications and strengths depend on the finished pharmaceutical formulation and local regulatory requirements.
Hydrocortisone Valerate provides topical glucocorticoid activity and is formulated to deliver corticosteroid action directly to affected skin. Its ester structure influences its lipophilicity, skin penetration and formulation characteristics.
Hydrocortisone Valerate is a synthetic steroid ester generally appearing as a white or almost white crystalline powder. It has very low solubility in water and is soluble in selected organic solvents.
The molecule contains the characteristic corticosteroid steroid nucleus and a valerate ester group.
Hydrocortisone Valerate API quality evaluation may include:
Hydrocortisone Valerate should be stored in a tightly closed container under controlled pharmaceutical conditions and protected from excessive heat, moisture and direct light. Storage conditions should follow validated stability data and the applicable product specification.
Hydrocortisone Valerate is relevant to pharmaceutical development involving topical glucocorticoids, inflammatory skin disorders, corticosteroid receptor activity and dermatological formulations.
Hydrocortisone Valerate is a synthetic topical glucocorticoid corticosteroid with CAS Number 575-90-6, molecular formula C26H36O6, and molecular weight 444.57 g/mol. It is primarily used as an active ingredient in topical dermatological formulations for corticosteroid-responsive inflammatory skin conditions.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | 97.0% – 103.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |
| Melting Point | Approximately 220–224°C, |