Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a direct-acting vasodilator used primarily in the management of hypertension. It acts predominantly on arteriolar smooth muscle, producing relaxation of peripheral resistance vessels and reducing systemic vascular resistance.
Hydralazine Hydrochloride is an established pharmaceutical active ingredient used in oral and injectable formulations, depending on the product and clinical application.
Hydralazine Hydrochloride is a synthetic cardiovascular pharmaceutical API requiring controlled chemical synthesis, purification and analytical characterization. Quality control focuses on identity, assay, related substances, water content, residual solvents and control of elemental impurities.
CAS Number: 304-20-1
Molecular Formula: C8H9ClN4
Molecular Weight: 196.64 g/mol
Chemical Name: Hydralazine Hydrochloride
Drug Class: Vasodilator
Pharmacological Class: Direct-Acting Arteriolar Vasodilator
Therapeutic Class: Antihypertensive
Therapeutic Area: Cardiovascular
Hydralazine produces direct relaxation of arteriolar vascular smooth muscle, leading to decreased peripheral vascular resistance.
The reduction in arterial resistance lowers blood pressure. Hydralazine can also trigger compensatory sympathetic responses, including increased heart rate and cardiac output, which is one reason it may be used in combination with other cardiovascular medicines.
Hydralazine Hydrochloride is used in the treatment of:
The exact indication depends on the dosage form and applicable regulatory labeling.
Hydralazine primarily lowers systemic vascular resistance through arteriolar dilation. Because it has comparatively less direct effect on venous capacitance vessels, its principal hemodynamic action is reduction of arterial resistance.
Hydralazine Hydrochloride is a synthetic nitrogen-containing heterocyclic compound supplied as a hydrochloride salt. It is generally obtained as a white to off-white crystalline powder and is soluble in water.
The hydrochloride salt provides a stable pharmaceutical form suitable for incorporation into dosage forms.
Hydralazine Hydrochloride API quality evaluation may include:
Hydralazine Hydrochloride should be stored in a tightly closed container, protected from excessive heat, moisture and direct light. Exact storage requirements should follow validated stability data and the applicable product-specific specification.
Hydralazine Hydrochloride remains relevant to pharmaceutical research involving arteriolar vasodilation, vascular smooth-muscle relaxation, blood-pressure regulation and cardiovascular pharmacology.
Hydralazine Hydrochloride is a direct-acting arteriolar vasodilator with CAS Number 304-20-1, molecular formula C8H9ClN4, and molecular weight 196.64 g/mol. It lowers blood pressure primarily by reducing peripheral arteriolar resistance and is used in selected antihypertensive treatment settings.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 3.5 – 5.5 |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |