Homatropine Methylbromide is a synthetic anticholinergic and antimuscarinic pharmaceutical ingredient derived from the tropane alkaloid family. It is the methyl bromide quaternary ammonium salt of homatropine and produces antimuscarinic effects by competitively inhibiting acetylcholine at muscarinic receptors.
Homatropine Methylbromide has the molecular formula C17H24BrNO3 and a molecular weight of 370.28 g/mol. Its CAS Number is 80-40-0.
Homatropine Methylbromide is a quaternary ammonium antimuscarinic compound. The permanent positive charge of its quaternary ammonium group limits its penetration across the blood-brain barrier compared with tertiary amine anticholinergic compounds.
It has historically been used for its antispasmodic and anticholinergic properties and has applications in pharmaceutical formulation and analytical research.
Homatropine Methylbromide acts as a competitive antagonist at muscarinic acetylcholine receptors.
By inhibiting muscarinic receptor stimulation, it can reduce parasympathetic effects such as:
Homatropine Methylbromide has applications in:
Homatropine Methylbromide is produced through controlled chemical synthesis involving preparation of the homatropine component followed by quaternization with a methylating agent to form the methyl bromide salt.
The resulting material undergoes purification, drying and quality-control testing to meet the applicable specification.
Homatropine Methylbromide is generally described as a white crystalline powder or crystalline solid. As a quaternary ammonium bromide salt, it has appreciable water solubility compared with the corresponding free-base/tertiary amine form.
Store Homatropine Methylbromide in a tightly closed container, protected from excessive moisture, heat and direct light. Follow the manufacturer's current CoA, SDS and validated stability conditions.
Depending on grade and intended application, documentation may include:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| pH (1% Solution) | 5.0 – 8.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |
| Specific Rotation | −20° to −30° |
| Melting Point | Approximately 250°C (decomposition) |