Hexamidine Diisethionate is a synthetic cosmetic preservative and antimicrobial ingredient used in personal-care formulations where controlled microbial growth is required. It is the diisethionate salt of Hexamidine and is valued for its water solubility and compatibility with a range of topical cosmetic formulations.
Hexamidine Diisethionate is identified by CAS Number 659-40-5 and EC Number 211-533-5. The molecular formula is C₂₄H₃₈N₄O₁₀S₂, with a molecular weight of approximately 606.70 g/mol. It is generally supplied as a white to light-yellow crystalline powder and is soluble in water.
The ingredient has a long history of use in topical preparations and is particularly relevant to cosmetic formulations requiring preservative functionality at relatively low use concentrations.
Hexamidine Diisethionate is chemically a salt formed from Hexamidine and two molecules of isethionic acid. The parent Hexamidine has the chemical structure 4,4′-(1,6-hexanediylbis(oxy))bis-benzenecarboximidamide. Hexamidine Diisethionate is also known by names including Hexamidine Isethionate, Hexamidine Diisethionate and Hexomedin.
The CAS Number 659-40-5, EC Number 211-533-5, molecular formula and molecular weight should be associated specifically with the diisethionate salt, rather than with Hexamidine base. This distinction is important because Hexamidine itself has a different molecular formula and molecular weight.
Hexamidine Diisethionate is reported as a white or light-yellow crystalline powder with good water solubility. Its water solubility is one of the characteristics that makes the salt form practical for aqueous cosmetic and personal-care formulations.
Hexamidine Diisethionate is primarily used as a preservative in cosmetic formulations. Cosmetic ingredient references also associate it with skin conditioning, emollient and antifoaming functions.
Its main formulation role is associated with controlling the growth of microorganisms and supporting the microbiological stability of cosmetic products. It can therefore be considered in formulations where preservation is required and where the formulation system is compatible with the ingredient.
Research on Hexamidine salts has also examined their antimicrobial activity and interaction with skin-related biological processes. However, technical or laboratory activity should not be interpreted as a universal cosmetic claim. The finished formulation must be assessed according to its intended function, concentration and applicable regulations.
Hexamidine Diisethionate Cosmetic Ingredient can be considered for a variety of skin-care and personal-care formulations, including creams, lotions, gels, cleansers and other topical cosmetic systems.
Its water solubility makes it particularly relevant to aqueous formulations. It can be incorporated into suitable water phases according to the formulation process and the manufacturer's recommended technical procedure.
The ingredient may also be considered in formulations designed for skin-conditioning and microbiological stability. Cosmetic formulation developers should evaluate compatibility with surfactants, humectants, emulsifiers, active ingredients and other preservatives.
Because Hexamidine Diisethionate is a regulated preservative in certain markets, the finished-product concentration must be determined according to the applicable cosmetic regulations rather than simply applying a generic formulation percentage.
Hexamidine Diisethionate should be evaluated according to its actual commercial grade and validated specification. Important quality-control parameters can include identification, assay, water content, pH, residue on ignition, heavy metals and related impurities.
Because the ingredient is supplied as a salt containing isethionate groups, the molecular weight and assay basis should be clearly defined. An HPLC assay should not be invented where the actual supplier specification uses another validated analytical method.
For EU cosmetic products, ECHA's current Annex V listing identifies Hexamidine Diisethionate as an allowed preservative for all cosmetic products, with a maximum concentration value of 0.1%, expressed for Hexamidine and its salts under the relevant entry.
The Cosmetic Ingredient Review has also concluded that Hexamidine and Hexamidine Diisethionate are safe for cosmetic use at concentrations up to 0.10% under the assessed conditions.
These regulatory limits should not be treated as a universal global formulation limit. Requirements can differ by market and product category.
Hexamidine Diisethionate is a specialty preservative ingredient for manufacturers developing skin-care and personal-care formulations. A reliable Hexamidine Diisethionate Cosmetic Ingredient Manufacturer in India can provide material with defined chemical identity, purity and technical characteristics for formulation and procurement requirements.
As a Hexamidine Diisethionate manufacturer and supplier in India, Swapnroop can support bulk requirements for cosmetic raw materials and specialty personal-care ingredients. Product specifications can be established according to the intended application, analytical requirements and customer quality standards.
For commercial manufacturing, consistent control of identity, purity, moisture, physical characteristics and other relevant quality parameters is important for reproducible formulation performance.
| Parameter | Specification |
|---|---|
| Appearance | White or colourless crystals / white powder |