Hexachlorophene is a chlorinated bisphenolic antibacterial and antiseptic compound that has historically been used as a topical antimicrobial agent. It inhibits the growth of susceptible microorganisms and has been incorporated into certain antiseptic and dermatological preparations.
Hexachlorophene is primarily recognized for its activity against Gram-positive bacteria, although its antimicrobial spectrum and clinical usefulness depend on concentration and formulation.
Hexachlorophene is a specialized dermatological pharmaceutical ingredient requiring controlled chemical synthesis, purification and analytical characterization. Quality control focuses on chemical identity, assay, related substances and control of residual impurities.
Because of its historical safety concerns with inappropriate or excessive exposure, pharmaceutical use is subject to formulation, concentration and regulatory requirements.
CAS Number: 70-30-4
Molecular Formula: C13H6Cl6O2
Molecular Weight: 406.90 g/mol
Chemical Name: 2,2′-Methylenebis(3,4,6-trichlorophenol)
Drug Class: Antiseptic / Antibacterial Agent
Pharmacological Class: Bisphenolic Antimicrobial
Therapeutic Class: Topical Anti-infective
Therapeutic Area: Dermatology / Antisepsis
Hexachlorophene exerts its antimicrobial effect primarily by disrupting bacterial cell membranes and cellular processes. It interferes with membrane-associated functions and can inhibit bacterial growth.
Its activity is particularly pronounced against many Gram-positive organisms.
Hexachlorophene has historically been used in:
Its current pharmaceutical use is restricted in many jurisdictions because systemic absorption and repeated exposure can produce serious adverse effects.
Hexachlorophene has strong antimicrobial activity at appropriate topical concentrations. However, because the compound can be absorbed through the skin, especially under conditions that increase absorption, its use requires appropriate formulation and regulatory controls.
Hexachlorophene is a highly chlorinated bisphenolic compound. It is generally obtained as a white to off-white crystalline powder and has very low water solubility. Its lipophilic nature contributes to its ability to interact with biological membranes.
Hexachlorophene API quality evaluation may include:
Hexachlorophene should be stored in a tightly closed container under controlled pharmaceutical conditions and protected from excessive heat, moisture and direct light. Handling should follow applicable safety and regulatory requirements.
Hexachlorophene remains relevant primarily as a reference antimicrobial compound and for research involving topical antiseptics, membrane-active antibacterial agents and historical dermatological formulations.
Hexachlorophene is a chlorinated bisphenolic antimicrobial compound with CAS Number 70-30-4, molecular formula C13H6Cl6O2, and molecular weight 406.90 g/mol. It has historically been used as a topical antibacterial and antiseptic agent, particularly against Gram-positive bacteria.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Heavy Metals | NMT 20 ppm |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 163–165°C |