Heparin Sodium is a biological anticoagulant composed of sulfated glycosaminoglycan chains. It exerts its anticoagulant effect primarily by enhancing the activity of antithrombin, which inhibits key coagulation enzymes including thrombin (factor IIa) and factor Xa.
Heparin Sodium is widely used in pharmaceutical formulations for the prevention and treatment of venous and arterial thromboembolic conditions and for maintaining anticoagulation during certain medical procedures.
Heparin Sodium is a specialized biological pharmaceutical API. Unlike conventional synthetic small-molecule APIs, it is a heterogeneous polysaccharide material whose quality depends on source material, extraction, purification, molecular-weight distribution, anticoagulant activity and impurity control.
Pharmaceutical-grade Heparin Sodium requires extensive analytical characterization and control of biological and microbiological impurities.
Product Name: Heparin Sodium
Common Name: Unfractionated Heparin
CAS Number: 9041-08-1
Molecular Formula: Variable / polymeric
Molecular Weight: Variable; typically approximately 12–15 kDa for unfractionated heparin
Drug Class: Anticoagulant
Pharmacological Class: Heparin / Antithrombin Activator
Therapeutic Class: Antithrombotic
Therapeutic Area: Hematology / Cardiovascular Medicine
Heparin binds to antithrombin (AT) and produces a conformational change that substantially accelerates antithrombin-mediated inhibition of activated coagulation factors.
Its anticoagulant activity is primarily associated with inhibition of factor Xa and thrombin (factor IIa). Heparin therefore reduces thrombin generation and fibrin formation, limiting the development and extension of blood clots.
Heparin Sodium is used for:
Specific uses depend on the formulation, dosage and approved product labeling.
Heparin provides rapid anticoagulant activity and is particularly useful when immediate modulation of coagulation is required. Its biological activity is commonly standardized using international units (IU) rather than relying solely on a conventional mass-based assay.
Heparin Sodium is a highly sulfated, negatively charged polysaccharide supplied as the sodium salt. It is generally obtained as a white or nearly white hygroscopic powder and is readily soluble in water.
Because heparin consists of heterogeneous polysaccharide chains, it does not have a single defined molecular formula or molecular weight like a conventional small molecule.
Heparin Sodium API quality evaluation may include:
Heparin Sodium should be stored in a tightly closed container under controlled pharmaceutical conditions and protected from excessive heat, moisture and direct light. Exact storage requirements should follow validated stability data and the applicable product-specific specification.
Heparin Sodium remains an important biological anticoagulant for pharmaceutical research involving coagulation pathways, antithrombin activity, thrombin inhibition and factor Xa inhibition.
Heparin Sodium is a biological anticoagulant polysaccharide with CAS Number 9041-08-1. Unlike conventional small molecules, it has a variable molecular structure and molecular-weight distribution. Its anticoagulant activity is primarily mediated through enhancement of antithrombin activity against factor Xa and thrombin.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| pH (1% Solution) | 5.5 – 8.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |