Halobetasol Propionate is a highly potent synthetic topical corticosteroid used to reduce inflammation, redness, itching and other symptoms associated with corticosteroid-responsive skin conditions. It belongs to the glucocorticoid class and is formulated for topical dermatological use.
Halobetasol Propionate is primarily used in the treatment of inflammatory and pruritic skin disorders such as plaque psoriasis and corticosteroid-responsive dermatoses.
Halobetasol Propionate is a high-potency dermatological pharmaceutical API requiring controlled steroid synthesis, purification and comprehensive impurity profiling. Manufacturing and quality control focus on chemical identity, assay, related substances, stereochemical integrity and residual impurities.
CAS Number: 66852-54-8
Molecular Formula: C25H31ClF2O5
Molecular Weight: 484.96 g/mol
Chemical Name: Halobetasol Propionate
Drug Class: Corticosteroid
Pharmacological Class: Topical Glucocorticoid
Therapeutic Class: Dermatological / Anti-inflammatory
Therapeutic Area: Dermatology
Halobetasol Propionate acts by binding to intracellular glucocorticoid receptors in target cells. The activated receptor complex influences gene transcription and suppresses the production and release of inflammatory mediators.
This results in reduced inflammation, erythema, edema and itching associated with corticosteroid-responsive skin disorders.
Halobetasol Propionate is used topically for inflammatory and pruritic corticosteroid-responsive dermatoses, including:
Specific approved uses depend on the finished formulation and regulatory labeling.
Halobetasol Propionate is considered a super-high-potency topical corticosteroid. Because of its high potency, topical formulations are generally intended for appropriate short-term use and under suitable medical direction.
Halobetasol Propionate is a synthetic fluorinated corticosteroid ester. It is generally obtained as a white to off-white crystalline powder and has very low water solubility, consistent with its lipophilic steroid structure.
Halobetasol Propionate API quality evaluation may include:
Halobetasol Propionate should be stored in a tightly closed container under controlled pharmaceutical conditions and protected from excessive heat, moisture and direct light. Exact storage conditions should follow validated stability data and the applicable product-specific specification.
Halobetasol Propionate is an established topical corticosteroid used in dermatological pharmaceutical development, particularly for formulations designed to provide potent local anti-inflammatory and antipruritic activity.
Halobetasol Propionate is a high-potency synthetic topical glucocorticoid with CAS Number 66852-54-8, molecular formula C25H31ClF2O5, and molecular weight 484.96 g/mol. It is primarily used in topical formulations for psoriasis and other corticosteroid-responsive inflammatory skin disorders.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | ≤3.0% |
| Water Content | NMT 1.0% |