Guanabenz is a centrally acting alpha-2 adrenergic receptor agonist that was developed as an antihypertensive agent. It reduces sympathetic nervous system activity, resulting in decreased peripheral vascular resistance and a reduction in blood pressure.
Guanabenz is commonly associated with its pharmaceutical salt form, guanabenz acetate.
Guanabenz is a specialized cardiovascular pharmaceutical active ingredient. Its production involves controlled chemical synthesis, purification and analytical testing to achieve consistent identity, assay and impurity control.
CAS Number: 5051-62-7
Molecular Formula: C17H17Cl2N5O
Molecular Weight: 378.26 g/mol
Common Salt Form: Guanabenz Acetate
Drug Class: Alpha-2 Adrenergic Agonist
Therapeutic Class: Antihypertensive
Therapeutic Area: Cardiovascular
Guanabenz acts primarily on central alpha-2 adrenergic receptors. Activation of these receptors reduces sympathetic outflow from the central nervous system.
The resulting decrease in sympathetic activity reduces vascular resistance and can lower heart rate and blood pressure.
Guanabenz was developed for the treatment of hypertension. It belongs to the centrally acting sympatholytic group of antihypertensive agents.
By decreasing central sympathetic nervous system activity, guanabenz can reduce the signals responsible for maintaining vascular tone and cardiac stimulation. This produces an antihypertensive effect.
Guanabenz is a synthetic small-molecule compound containing a dichlorobenzylidene hydrazine-related structure. It is generally supplied as a crystalline solid, while guanabenz acetate is the corresponding pharmaceutical salt.
Guanabenz API quality evaluation may include:
Guanabenz should be stored in a tightly closed container under controlled pharmaceutical conditions and protected from excessive heat, moisture and direct light. Exact storage conditions should follow validated stability data and the applicable product-specific specification.
Guanabenz remains of interest as a reference compound for research involving central adrenergic signaling, sympathetic regulation and antihypertensive pharmacology.
Guanabenz is a centrally acting alpha-2 adrenergic agonist developed as an antihypertensive agent. It has CAS Number 5051-62-7, molecular formula C17H17Cl2N5O, and molecular weight 378.26 g/mol. Its pharmacological action is associated with reducing central sympathetic outflow and lowering blood pressure.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |
| Melting Point | Approximately 238–242°C, with decomposition |