Grepafloxacin is a synthetic fluoroquinolone antibacterial active pharmaceutical ingredient (API) with the molecular formula C19H22FN3O3 and a molecular weight of 359.39 g/mol. It is chemically identified as 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid. Grepafloxacin is a quinolone antibacterial compound that was developed for oral antimicrobial use.
Grepafloxacin belongs to the fluoroquinolone class of antibacterial compounds. The API is supplied as a synthetic pharmaceutical intermediate or active ingredient according to applicable quality and regulatory requirements. The free-base compound is identified by CAS Number 119914-60-2. Grepafloxacin hydrochloride is the corresponding hydrochloride salt and has been used in pharmaceutical formulations.
Grepafloxacin has the molecular formula C19H22FN3O3 and a molecular weight of 359.39 g/mol. It is reported as a solid with a melting point of approximately 189–192°C. The compound has limited water solubility, while solubility can vary depending on pH, salt form and solvent system.
Grepafloxacin API quality can be evaluated through identity testing, chromatographic purity, assay, residual solvents, water content, elemental impurities and other applicable quality-control parameters. Batch-specific analytical values should be confirmed against the manufacturer's current Certificate of Analysis (CoA) and applicable specification.
Grepafloxacin should be stored in a tightly closed container under appropriate controlled conditions, protected from excessive heat, moisture and direct light. The exact storage condition should follow the manufacturer's current CoA, specification and stability data.
For pharmaceutical development and sourcing requirements, Grepafloxacin can be evaluated according to the required grade, specification, documentation and intended application. Contact us for product specifications, technical documentation and availability.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms to structure by HPLC / MS / NMR |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.0 – 8.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 189 – 192°C |