Golidocitinib is a selective Janus kinase 1 (JAK1) inhibitor developed as an orally active small-molecule pharmaceutical compound. It is also known by the development code AZD4205. Golidocitinib has the molecular formula C25H31N9O2 and a molecular weight of approximately 489.57 g/mol. Its CAS Number is 2091134-68-6.
Golidocitinib selectively inhibits JAK1-dependent signaling pathways involved in cytokine-mediated cellular activity. The compound has been investigated for its potential antineoplastic activity and has been studied particularly in hematological malignancies.
Golidocitinib is supplied as a solid material. Commercial research-grade sources describe the material as light yellow to yellow or solid in appearance, while published synthetic work has also described isolated material as a white solid depending on the preparation and form.
For pharmaceutical development and API applications, identification and chromatographic purity are important quality attributes. Publicly available supplier data reports Golidocitinib at ≥99% HPLC purity, while other suppliers report 98–99.8% grades.
Golidocitinib is primarily investigated as a pharmaceutical active ingredient and research compound targeting JAK1. It has been studied in oncology research, including investigations involving peripheral T-cell lymphoma and other malignancies.
Golidocitinib API manufacturing involves controlled chemical synthesis, purification and analytical testing to establish identity, purity and consistency. Appropriate quality-control testing may include chromatographic purity, identity testing, residual solvents, water content, elemental impurities and other parameters according to the applicable manufacturing specification.
Swaproop can provide information related to Golidocitinib API, including technical specifications, documentation and pharmaceutical sourcing requirements.
Golidocitinib is supplied as a solid/powder and should be stored under controlled conditions according to the applicable supplier or manufacturer specification. Research-product sources recommend frozen storage for the solid material.
Golidocitinib is a selective JAK1 inhibitor with an established chemical identity and growing pharmaceutical research interest. Its defined molecular structure, CAS number and high-purity availability make it a relevant compound for pharmaceutical research and API development.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms by HPLC / LC-MS |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 1.0% |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |