Glucarpidase API is a pharmaceutical-grade recombinant enzyme used for the emergency treatment of toxic plasma methotrexate concentrations in patients experiencing delayed methotrexate clearance due to impaired renal function. The enzyme rapidly hydrolyzes methotrexate into inactive metabolites, significantly reducing circulating methotrexate levels and helping minimize life-threatening toxicity.
Glucarpidase plays a critical role in oncology supportive care, particularly following high-dose methotrexate therapy. It provides rapid detoxification when conventional supportive treatments alone are insufficient, helping protect patients from severe renal, hepatic, hematologic, and gastrointestinal toxicities.
Swapnroop Drugs and Pharmaceuticals manufactures premium-quality Glucarpidase API under stringent WHO-GMP manufacturing standards. Every batch undergoes rigorous quality testing for purity, biological activity, sterility, stability, and consistency. Complete regulatory documentation, including Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and technical specifications, is provided.
Glucarpidase API is supplied in validated sterile pharmaceutical packaging suitable for commercial manufacturing and clinical applications.
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The CAS Number of Glucarpidase API is 129727-39-9.
Glucarpidase API is used for the emergency treatment of toxic methotrexate levels in patients with delayed methotrexate clearance due to impaired kidney function.
Glucarpidase rapidly breaks down methotrexate into inactive metabolites, lowering blood methotrexate concentrations and reducing the risk of severe toxicity.
Yes. We provide Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), technical specifications, and complete regulatory documentation.
Yes. We offer commercial bulk quantities with reliable worldwide export support.
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