Garenoxacin API is a synthetic quinolone antibacterial agent belonging to the des-fluoroquinolone class. It is also known by the development code T-3811 and is structurally related to the fluoroquinolone class, but lacks the conventional fluorine substituent at the C-6 position. Garenoxacin exhibits antibacterial activity against a broad range of Gram-positive and Gram-negative bacteria.
Garenoxacin has the molecular formula C₂₃H₂₀F₂N₂O₄, molecular weight 426.41 g/mol, and CAS Registry Number 194804-75-6. The molecule contains one defined stereocenter and is identified as the (R)-configuration.
For pharmaceutical use, Garenoxacin Mesylate is an important salt form. Garenoxacin mesylate has CAS 223652-90-2 and a molecular weight of 540.5 g/mol for the mesylate monohydrate.
| Property | Value |
|---|---|
| API Name | Garenoxacin |
| CAS Number | 194804-75-6 |
| Development Code | T-3811 / BMS-284756 |
| Molecular Formula | C₂₃H₂₀F₂N₂O₄ |
| Molecular Weight | 426.41 g/mol |
| Chemical Class | Des-fluoroquinolone / Quinolone |
| Pharmacological Class | Quinolone Antibacterial |
| Stereochemistry | (R) |
| Defined Stereocenters | 1 |
| Appearance | Solid |
| Mesylate Salt CAS | 223652-90-2 |
| Mesylate Monohydrate MW | 540.5 g/mol |
The free compound and mesylate forms must be kept separate in your CMS because their CAS numbers and molecular weights are different.
Garenoxacin is a quinolone antibacterial that acts primarily by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes required for bacterial DNA replication, transcription and chromosome maintenance.
Inhibition of these essential enzymes interferes with bacterial DNA processing and ultimately leads to bacterial cell death.
Garenoxacin has been investigated and used as an antibacterial agent for the treatment of bacterial infections involving susceptible microorganisms. It has activity against both Gram-positive and Gram-negative bacteria.
The API is relevant to:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Melting Point | 226–227°C |
| Solubility | Slightly soluble in DMF, DMSO and methanol when heated |